Characteristics of Oral-Gut Microbiota in Model Rats with CUMS-Induced Depression/Experiment 2

From BugSigDB


Reviewed Marked as Reviewed by Svetlana up on 2025-4-7

Curated date: 2025/04/02

Curator: Francisca

Revision editor(s): Francisca, Montana-D

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Rattus norvegicus
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Major depressive disorder major depression,major depressive disorder,recurrent major depression,single major depressive episode,unipolar depression,Major depressive disorder
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Control group (Rats without CUMS - induced depression
Group 1 name Corresponds to the case (exposed) group for case-control studies
CUMS group (Rats with chronic unpredictable mild stress- induced depression)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group consisted of rats subjected to a Chronic Unpredictable Mild Stress (CUMS) protocol to induce depressive-like symptoms.
Group 0 sample size Number of subjects in the control (unexposed) group
10
Group 1 sample size Number of subjects in the case (exposed) group
10

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
3

Alpha Diversity

Chao1 Abundance-based estimator of species richness
unchanged
Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-4-7

Curated date: 2025/04/02

Curator: Montana-D

Revision editor(s): Montana-D

Source: Figure 5B

Description: Comparison of gut microbiota between CUMS-induced depressed rats and control rats.

Abundance in Group 1: increased abundance in CUMS group (Rats with chronic unpredictable mild stress- induced depression)

NCBI Quality ControlLinks
Butyricicoccus
rc4_4rc4_4

Revision editor(s): Montana-D

Signature 2

Reviewed Marked as Reviewed by Svetlana up on 2025-4-7

Curated date: 2025/04/02

Curator: Montana-D

Revision editor(s): Montana-D, Francisca

Source: Figure 5B

Description: Comparison of gut microbiota between CUMS-induced depressed rats and control rats

Abundance in Group 1: decreased abundance in CUMS group (Rats with chronic unpredictable mild stress- induced depression)

NCBI Quality ControlLinks
Enterococcaceae
Enterococcaceae bacterium RF39
Enterococcus
Erysipelotrichales
Mollicutes
Streptococcaceae
Streptococcus
Turicibacter
Turicibacteraceae
Mycoplasmatota
TuricibateralesTuricibaterales

Revision editor(s): Montana-D, Francisca