Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case-control study/Experiment 1

From BugSigDB


Reviewed Marked as Reviewed by Atrayees on 2023-7-12

Curated date: 2021/01/10

Curator: WikiWorks

Revision editor(s): WikiWorks, Atrayees

Subjects

Location of subjects
Canada
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Vagina Vagina,vagina,Distal oviductal region,Distal portion of oviduct,Vaginae
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Premature birth Birth, Premature,Birth, Preterm,Births, Premature,Births, Preterm,Premature Births,Preterm Birth,Preterm Births,Premature birth,premature birth
Group 0 name Corresponds to the control (unexposed) group for case-control studies
mothers whose newborns were delivered at ≥37 getastional weeks
Group 1 name Corresponds to the case (exposed) group for case-control studies
mothers whose newborns were delivered at <34 gestational week
Group 0 sample size Number of subjects in the control (unexposed) group
365
Group 1 sample size Number of subjects in the case (exposed) group
17

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
NLMIXED
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes
Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
body mass index, ethnic group, smoking behavior, maternal age, parity


Signature 1

Reviewed Marked as Reviewed by Atrayees on 2023-7-12

Curated date: 2021/01/10

Curator: Shaimaa Elsafoury

Revision editor(s): WikiWorks

Source: Table 2 & S2

Description: Vaginal microbial oligotype differential relative abundance composition between pregnant women who had early (<34 weeks of gestation) preterm versus full term (≥37 weeks gestation) deliveries

Abundance in Group 1: decreased abundance in mothers whose newborns were delivered at <34 gestational week

NCBI Quality ControlLinks
Lactobacillus gasseri
Lactobacillus johnsonii
Bifidobacterium longum subsp. longum
Bifidobacterium breve
Lactobacillus acidophilus
Lactobacillus crispatus
Lactobacillus iners
Ralstonia solanacearum
Bifidobacterium

Revision editor(s): WikiWorks