Vaginal microbiome in early pregnancy and subsequent risk of spontaneous preterm birth: a case-control study/Experiment 1
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Reviewed Marked as Reviewed by Atrayees on 2023-7-12
Subjects
- Location of subjects
- Canada
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Vagina Vagina,vagina,Distal oviductal region,Distal portion of oviduct,Vaginae
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Premature birth Birth, Premature,Birth, Preterm,Births, Premature,Births, Preterm,Premature Births,Preterm Birth,Preterm Births,Premature birth,premature birth
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- mothers whose newborns were delivered at ≥37 getastional weeks
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- mothers whose newborns were delivered at <34 gestational week
- Group 0 sample size Number of subjects in the control (unexposed) group
- 365
- Group 1 sample size Number of subjects in the case (exposed) group
- 17
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- NLMIXED
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- body mass index, ethnic group, smoking behavior, maternal age, parity
Signature 1
Reviewed Marked as Reviewed by Atrayees on 2023-7-12
Source: Table 2 & S2
Description: Vaginal microbial oligotype differential relative abundance composition between pregnant women who had early (<34 weeks of gestation) preterm versus full term (≥37 weeks gestation) deliveries
Abundance in Group 1: decreased abundance in mothers whose newborns were delivered at <34 gestational week
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