The skin microbiome is different in pediatric versus adult atopic dermatitis/Experiment 3
From BugSigDB
Reviewed Marked as Reviewed by Atrayees on 2023-8-14
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Skin of body Entire integument,Entire skin,Integument,Integumental organ,Pelt,Skin,Skin organ,Skin of body,skin of body
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Age Age,age
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- 2-12 years
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- 13-62 years
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- teenager/adult age 13-62
- Group 0 sample size Number of subjects in the control (unexposed) group
- 59
- Group 1 sample size Number of subjects in the case (exposed) group
- 69
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 1 week (oral antibiotics)
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V1-V3
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- T-Test
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Matched on Factors on which subjects have been matched on in a case-control study
- age
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
Signature 1
Reviewed Marked as Reviewed by Atrayees on 2023-8-14
Source: Supplemental Table E4
Description: Taxonomic composition of the atopic dermatitis skin microbiome at the genus level among those with lesional skin
Abundance in Group 1: increased abundance in 13-62 years
| NCBI | Quality Control | Links |
|---|---|---|
| Propionibacterium | ||
| Corynebacterium | ||
| Lactobacillus |
Revision editor(s): WikiWorks
Signature 2
Reviewed Marked as Reviewed by Atrayees on 2023-8-14
Source: Supplemental Table E4
Description: Taxonomic composition of the atopic dermatitis skin microbiome at the genus level among those with lesional skin
Abundance in Group 1: decreased abundance in 13-62 years
| NCBI | Quality Control | Links |
|---|---|---|
| Streptococcus | ||
| Granulicatella | ||
| Gemella | ||
| Neisseria | ||
| Haemophilus | ||
| Rothia | ||
| Veillonella |
