Microbiota changes in a pediatric acute lymphocytic leukemia mouse model/Experiment 1
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Small intestine Anterior intestine,Intestinum tenue,Mid intestine,Small bowel,Small intestine,small intestine
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Acute lymphoblastic leukemia acute lymphoblastic leukemia,acute lymphoblastic leukemia (ALL),acute lymphoblastic leukemia (disease),acute lymphoblastic leukemia/lymphoma,acute lymphocytic leukaemia,acute lymphocytic leukemia,acute lymphocytic leukemias,acute lymphogenous leukemia,acute lymphoid leukemia,ALL,ALL - acute lymphocytic leukemia,leukemia, lymphoblastic, malignant,lymphoblastic leukemia,lymphoblastic leukemia, acute,precursor cell lymphoblastic leukemia,precursor Lymphoblasic leukemia,precursor lymphoblastic leukemia,Acute lymphoblastic leukemia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy Control
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Fecal bacterial composition in small intestines of leukemia mice
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Three-week old female mice induced leukemia using lymphomblasts from pediatric acture lymphocytic leukemia patients from ATCC
- Group 0 sample size Number of subjects in the control (unexposed) group
- 8
- Group 1 sample size Number of subjects in the case (exposed) group
- 8
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- MGISEQ-2000
Statistical Analysis
- Statistical test
- T-Test
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
Signature 1
Source: Figure 4a, 4b and text
Description: Relative abundances (a) and the ratio of relative abundances (b) of the bacterial microbiota between the fecal compositions in the small intestine of control and leukemic mice
Abundance in Group 1: increased abundance in Fecal bacterial composition in small intestines of leukemia mice
| NCBI | Quality Control | Links |
|---|---|---|
| Akkermansia | ||
| Anaeroplasma | ||
| Anaerostipes | ||
| Blautia | ||
| Butyrivibrio | ||
| Clostridium | ||
| Coprococcus | ||
| Dehalobacterium formicoaceticum | ||
| Dorea | ||
| Oscillospira | ||
| Ruminococcus |
Revision editor(s): WikiWorks, Peace Sandy
Signature 2
Source: Figure 4a, 4b and text
Description: Relative abundances (a) and the ratio of relative abundances (b) of the bacterial microbiota between the fecal compositions in the small intestine of control and leukemic mice
Abundance in Group 1: decreased abundance in Fecal bacterial composition in small intestines of leukemia mice
| NCBI | Quality Control | Links |
|---|---|---|
| Adlercreutzia | ||
| Lactobacillus | ||
| Turicibacter |
Revision editor(s): WikiWorks, Peace Sandy
