Molecular Alteration Analysis of Human Gut Microbial Composition in Graves' disease Patients/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Folakunmi on 2024-2-5
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Graves disease Basedow disease,Basedow's disease,exophthalmic goiter,Flajani-Basedow-Graves disease,grave's disease,Graves disease,Graves' disease,Graves' hyperthyroidism,parry disease,toxic diffuse goiter,graves disease
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- healthy controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- graves disease
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- graves' disease patients
- Group 0 sample size Number of subjects in the control (unexposed) group
- 11
- Group 1 sample size Number of subjects in the case (exposed) group
- 27
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 2 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Statistical test
- T-Test
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- Matched on Factors on which subjects have been matched on in a case-control study
- age
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Chao1 Abundance-based estimator of species richness
- decreased
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
- Richness Number of species
- decreased
Signature 1
Reviewed Marked as Reviewed by Folakunmi on 2024-2-5
Source: Fig 5, Fig6, Table 6,7 and text
Description: Gut microbial composition differences between Graves' disease and control at different levels
Abundance in Group 1: increased abundance in graves disease
| NCBI | Quality Control | Links |
|---|---|---|
| Prevotellaceae | ||
| Pasteurellaceae | ||
| Prevotella | ||
| Haemophilus | ||
| Campylobacter showae | ||
| Veillonella sp. | ||
| Morganella morganii |
Revision editor(s): WikiWorks
Signature 2
Reviewed Marked as Reviewed by Folakunmi on 2024-2-5
Source: Fig 5, Fig6, Table 6,7 and text
Description: Gut microbial composition differences between Graves' disease and control at different levels
Abundance in Group 1: decreased abundance in graves disease
| NCBI | Quality Control | Links |
|---|---|---|
| Alistipes | ||
| Alistipes sp. | ||
| Enterobacteriaceae | ||
| Faecalibacterium | ||
| Lactobacillus gasseri | ||
| Rikenellaceae | ||
| Veillonellaceae | ||
| Dialister |
