Intestinal microbiome analysis demonstrates azithromycin post-treatment effects improve when combined with lactulose/Experiment 3

From BugSigDB


Reviewed Marked as Reviewed by Folakunmi on 2024-2-21

Curated date: 2021/12/03

Curator: Mmarin

Revision editor(s): WikiWorks, LGeistlinger, Mmarin, Folakunmi

Subjects

Location of subjects
Russian Federation
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Antimicrobial agent antibiotic,antibiotics,Antibiotika,Antibiotikum,antibiotique,antimicrobial,antimicrobial agents,microbicide,microbicides,Antimicrobial agent,antimicrobial agent
Group 0 name Corresponds to the control (unexposed) group for case-control studies
azithromycin treated (day 0)
Group 1 name Corresponds to the case (exposed) group for case-control studies
azithromycin treated (day 60)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
administered 10 mg/kg body weight per day of azithromycin, as powder for oral suspension.
Group 0 sample size Number of subjects in the control (unexposed) group
42
Group 1 sample size Number of subjects in the case (exposed) group
42

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Mann-Whitney (Wilcoxon)
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05


Signature 1

Reviewed Marked as Reviewed by Folakunmi on 2024-2-20

Curated date: 2021/12/03

Curator: Mmarin

Revision editor(s): Mmarin

Source: Table 1

Description: Arrows point up or down indicate an increase or increase compared to the relative abundance at day 0, respectively

Abundance in Group 1: decreased abundance in azithromycin treated (day 60)

NCBI Quality ControlLinks
Enterobacter
Odoribacter
Paraprevotella
Prevotella
Sutterella

Revision editor(s): Mmarin

Signature 2

Reviewed Marked as Reviewed by Folakunmi on 2024-2-20

Curated date: 2021/12/03

Curator: Mmarin

Revision editor(s): Mmarin

Source: Table 1

Description: Arrows point up or down indicate an increase or increase compared to the relative abundance at day 0, respectively

Abundance in Group 1: increased abundance in azithromycin treated (day 60)

NCBI Quality ControlLinks
Adlercreutzia
Alkaliphilus
Streptococcus
Veillonella

Revision editor(s): Mmarin