The East Asian gut microbiome is distinct from colocalized White subjects and connected to metabolic health/Experiment 1

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Reviewed Marked as Reviewed by Peace Sandy on 2024-2-13

Curated date: 2022/06/08

Curator: Kaluifeanyi101

Revision editor(s): WikiWorks, Kaluifeanyi101, Aiyshaaaa, Peace Sandy

Subjects

Location of subjects
United States of America
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Ethnic group Ethnicity,race,Ethnic group,ethnic group
Group 0 name Corresponds to the control (unexposed) group for case-control studies
White (W)
Group 1 name Corresponds to the case (exposed) group for case-control studies
East Asian (EA)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
A balanced distribution of both lean and obese adults who identified as East Asians residing within the Bay area of San Fransisco.
Group 0 sample size Number of subjects in the control (unexposed) group
24
Group 1 sample size Number of subjects in the case (exposed) group
22
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
Unspecified

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Mann-Whitney (Wilcoxon)
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
decreased
Richness Number of species
decreased
Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
decreased

Signature 1

Reviewed Marked as Reviewed by Peace Sandy on 2024-2-13

Curated date: 2022/06/08

Curator: Kaluifeanyi101

Revision editor(s): Kaluifeanyi101, Aiyshaaaa, Peace Sandy

Source: Figure 1

Description: The gut microbiota is distinct between East Asian (EA) and White (W) subjects living in the Bay Area. (C) CLR abundances of all bacterial phyla between EA and W subjects. p-values determined using Wilcoxon rank-sum tests.

Abundance in Group 1: increased abundance in East Asian (EA)

NCBI Quality ControlLinks
Bacteroidota

Revision editor(s): Kaluifeanyi101, Aiyshaaaa, Peace Sandy

Signature 2

Reviewed Marked as Reviewed by Peace Sandy on 2024-2-13

Curated date: 2022/06/08

Curator: Kaluifeanyi101

Revision editor(s): Kaluifeanyi101, Aiyshaaaa, Peace Sandy

Source: Figure 1

Description: The gut microbiota is distinct between East Asian (EA) and White (W) subjects living in the Bay Area. (C) CLR abundances of all bacterial phyla between EA and W subjects. p-values determined using Wilcoxon rank-sum tests.

Abundance in Group 1: decreased abundance in East Asian (EA)

NCBI Quality ControlLinks
Bacillota
Actinomycetes bacterium
Verrucomicrobiota
Fusobacteriota
Synergistota
Campylobacterota

Revision editor(s): Kaluifeanyi101, Aiyshaaaa, Peace Sandy