Toxic metals impact gut microbiota and metabolic risk in five African-origin populations
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Quality control
- Retracted paper
- Contamination issues suspected
- Batch effect issues suspected
- Uncontrolled confounding suspected
- Results are suspect (various reasons)
- Tags applied
Experiment 1
Curated date: 2025/05/05
Curator: PreciousChijioke
Revision editor(s): Chloe, Anne-mariesharp, PreciousChijioke
Subjects
- Location of subjects
- Ghana
- Jamaica
- Seychelles
- South Africa
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Metabolic toxicity Metabolic toxicity,metabolic toxicity
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low lead exposure
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High lead exposure
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high lead exposure
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 3 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 3
Signature 1
Source: Figure 2A
Description: Differential taxa by metal exposure.
Abundance in Group 1: increased abundance in High lead exposure
Revision editor(s): Chloe, Anne-mariesharp
Experiment 2
Curated date: 2025/05/05
Curator: PreciousChijioke
Revision editor(s): Chloe, Anne-mariesharp, PreciousChijioke
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low arsenic exposure
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High arsenic exposure
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high arsenic exposure
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 2B
Description: Differential taxa by metal exposure.
Abundance in Group 1: increased abundance in High arsenic exposure
Revision editor(s): Chloe, Anne-mariesharp
Signature 2
Source: Figure 2B
Description: Differential taxa by metal exposure.
Abundance in Group 1: decreased abundance in High arsenic exposure
| NCBI | Quality Control | Links |
|---|---|---|
| Anaerostipes | ||
| Coprobacillaceae | ||
| Fusicatenibacter | ||
| Mediterraneibacter gnavus | ||
| Oscillospiraceae |
Revision editor(s): Chloe, Anne-mariesharp
Experiment 3
Curated date: 2025/05/05
Curator: PreciousChijioke
Revision editor(s): Chloe, Anne-mariesharp, PreciousChijioke
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low Mercury exposure
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High Mercury exposure
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high mercury exposure
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 2C
Description: Differential taxa by metal exposure.
Abundance in Group 1: decreased abundance in High Mercury exposure
| NCBI | Quality Control | Links |
|---|---|---|
| Anaerostipes |
Revision editor(s): Chloe, Anne-mariesharp
Experiment 4
Curated date: 2025/05/05
Curator: PreciousChijioke
Revision editor(s): Chloe, Anne-mariesharp, PreciousChijioke
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-diabetic (high lead exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Diabetic (high lead exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants diagnosed with T2DM (Type 2 Diabetes Mellitus) within the high lead exposure group
Lab analysis
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- arcsine square-root
- Statistical test
- MaAsLin2
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- Not specified
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, sex, Confounders controlled for: "site" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.site
Signature 1
Source: Figure 3A
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in Diabetic (high lead exposure)
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3A
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in Diabetic (high lead exposure)
Revision editor(s): Anne-mariesharp
Experiment 5
Curated date: 2025/05/05
Curator: PreciousChijioke
Revision editor(s): Chloe, Anne-mariesharp, PreciousChijioke
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low diastolic blood pressure (DBP) (high lead exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High diastolic blood pressure (DBP) (high lead exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high diastolic blood pressure (DBP) within the high lead exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3A
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in High diastolic blood pressure (DBP) (high lead exposure)
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3A
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in High diastolic blood pressure (DBP) (high lead exposure)
Revision editor(s): Anne-mariesharp
Experiment 6
Curated date: 2025/05/05
Curator: PreciousChijioke
Revision editor(s): Chloe, Anne-mariesharp, PreciousChijioke
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low body mass index (BMI) (high lead exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High body mass index (BMI) (high lead exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high body mass index (BMI) within the high lead exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3A
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in High body mass index (BMI) (high lead exposure)
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3A
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in High body mass index (BMI) (high lead exposure)
Revision editor(s): Anne-mariesharp
Experiment 7
Curated date: 2025/05/05
Curator: PreciousChijioke
Revision editor(s): Chloe, Anne-mariesharp, PreciousChijioke
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-hypertensive (high lead exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hypertensive (high lead exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with hypertension within the high lead exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3A
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in Hypertensive (high lead exposure)
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3A
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in Hypertensive (high lead exposure)
Revision editor(s): Anne-mariesharp
Experiment 8
Curated date: 2025/05/05
Curator: PreciousChijioke
Revision editor(s): Chloe, Anne-mariesharp, PreciousChijioke
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low glucose result (high lead exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High glucose result (high lead exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high glucose result within the high lead exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3A
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in High glucose result (high lead exposure)
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3A
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in High glucose result (high lead exposure)
Revision editor(s): Anne-mariesharp
Experiment 9
Curated date: 2025/05/05
Curator: PreciousChijioke
Revision editor(s): Chloe, Anne-mariesharp, PreciousChijioke
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low lead exposure
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High lead exposure
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high lead exposure
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3A, 5A
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in High lead exposure
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3A, 5A
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in High lead exposure
Revision editor(s): Anne-mariesharp
Experiment 10
Curated date: 2025/05/05
Curator: PreciousChijioke
Revision editor(s): Chloe, Anne-mariesharp, PreciousChijioke
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low glucose result (high arsenic exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High glucose result (high arsenic exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high glucose result within the high arsenic exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3B
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in High glucose result (high arsenic exposure)
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3B
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in High glucose result (high arsenic exposure)
Revision editor(s): Anne-mariesharp
Experiment 11
Curated date: 2025/05/05
Curator: PreciousChijioke
Revision editor(s): Chloe, Anne-mariesharp, PreciousChijioke
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-hypertensive (high arsenic exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hypertensive (high arsenic exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with hypertension within the high arsenic exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3B
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in Hypertensive (high arsenic exposure)
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3B
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in Hypertensive (high arsenic exposure)
Revision editor(s): Anne-mariesharp
Experiment 12
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low body mass index (BMI) (high arsenic exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High body mass index (BMI) (high arsenic exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high body mass index (BMI) within the high arsenic exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3B
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in High body mass index (BMI) (high arsenic exposure)
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3B
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in High body mass index (BMI) (high arsenic exposure)
Revision editor(s): Anne-mariesharp
Experiment 13
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low diastolic blood pressure (DBP) (high arsenic exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High diastolic blood pressure (DBP) (high arsenic exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high diastolic blood pressure (DBP) within the high arsenic exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3B
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in High diastolic blood pressure (DBP) (high arsenic exposure)
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3B
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in High diastolic blood pressure (DBP) (high arsenic exposure)
Revision editor(s): Anne-mariesharp
Experiment 14
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low arsenic exposure
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High arsenic exposure
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high arsenic exposure
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3B, Figure 5A
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in High arsenic exposure
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3B, Figure 5A
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in High arsenic exposure
Revision editor(s): Anne-mariesharp
Experiment 15
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-diabetic (high arsenic exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Diabetic (high arsenic exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants diagnosed with T2DM (Type 2 Diabetes Mellitus) within the high arsenic exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3B
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in Diabetic (high arsenic exposure)
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3B
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in Diabetic (high arsenic exposure)
Revision editor(s): Anne-mariesharp
Experiment 16
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-diabetic (high cadmium exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Diabetic (high cadmium exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants diagnosed with T2DM (Type 2 Diabetes Mellitus) within the high cadmium exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3C
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in Diabetic (high cadmium exposure)
| NCBI | Quality Control | Links |
|---|---|---|
| Pediococcus | ||
| Family XIII AD3011 groupFamily XIII AD3011 group | ||
| Rothia mucilaginosa | ||
| Neisseria | ||
| Rothia | ||
| Haemophilus | ||
| Collinsella | ||
| Intestinimonas | ||
| Blautia | ||
| Clostridium |
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3C
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in Diabetic (high cadmium exposure)
Revision editor(s): Anne-mariesharp
Experiment 17
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low diastolic blood pressure (high cadmium exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High diastolic blood pressure (high cadmium exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high diastolic blood pressure within the high cadmium exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3C
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in High diastolic blood pressure (high cadmium exposure)
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3C
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in High diastolic blood pressure (high cadmium exposure)
Revision editor(s): Anne-mariesharp
Experiment 18
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low cadmium exposure
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High cadmium exposure
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high cadmium exposure
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3C
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in High cadmium exposure
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3C
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in High cadmium exposure
Revision editor(s): Anne-mariesharp
Experiment 19
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low glucose result (high cadmium exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High glucose result (high cadmium exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high glucose result within the high cadmium exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3C
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in High glucose result (high cadmium exposure)
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3C
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in High glucose result (high cadmium exposure)
| NCBI | Quality Control | Links |
|---|---|---|
| Family XIII AD3011 groupFamily XIII AD3011 group | ||
| Christensenellaceae R-7 groupChristensenellaceae R-7 group | ||
| Enterorhabdus | ||
| Blautia |
Revision editor(s): Anne-mariesharp
Experiment 20
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-hypertensive (high cadmium exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hypertensive (high cadmium exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with hypertension within the high cadmium exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3C
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in Hypertensive (high cadmium exposure)
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3C
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in Hypertensive (high cadmium exposure)
| NCBI | Quality Control | Links |
|---|---|---|
| Prevotella_9Prevotella_9 | ||
| Colidextribacter | ||
| Paraprevotella | ||
| Alistipes indistinctus | ||
| UCG 005UCG 005 | ||
| Howardella ureilytica | ||
| Neisseria | ||
| Intestinimonas |
Revision editor(s): Anne-mariesharp
Experiment 21
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low body mass index (BMI) (high cadmium exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High body mass index (BMI) (high cadmium exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high body mass index within the high cadmium exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3C
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in High body mass index (BMI) (high cadmium exposure)
| NCBI | Quality Control | Links |
|---|---|---|
| Corynebacterium | ||
| Streptococcus | ||
| Mitsuokella multacida | ||
| Prevotella_9Prevotella_9 | ||
| Christensenellaceae R-7 groupChristensenellaceae R-7 group | ||
| Clostridium | ||
| Peptococcus |
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 3C
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in High body mass index (BMI) (high cadmium exposure)
Revision editor(s): Anne-mariesharp
Experiment 22
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low body mass index (BMI) (high mercury exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High body mass index (BMI) (high mercury exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high body mass index within the high mercury exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3D
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in High body mass index (BMI) (high mercury exposure)
| NCBI | Quality Control | Links |
|---|---|---|
| Fusobacterium | ||
| Rothia |
Revision editor(s): Anne-mariesharp
Experiment 23
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low glucose result (high mercury exposure)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High glucose result (high mercury exposure)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high glucose result within the high mercury exposure group
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3D
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: increased abundance in High glucose result (high mercury exposure)
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteria incertae sedis | ||
| Alistipes indistinctus | ||
| Parolsenella |
Revision editor(s): Anne-mariesharp
Experiment 24
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low mercury exposure
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High mercury exposure
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high mercury exposure
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 3D
Description: Differential taxa by individual metal exposure and cardiometabolic disease
Abundance in Group 1: decreased abundance in High mercury exposure
| NCBI | Quality Control | Links |
|---|---|---|
| Candidatus Soleaferrea | ||
| Syntrophococcus | ||
| Sporobacter | ||
| Lachnospiraceae bacterium NK3A20 | ||
| Lachnospiraceae UCG 002Lachnospiraceae UCG 002 |
Revision editor(s): Anne-mariesharp
Experiment 25
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low diastolic blood pressure
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High diastolic blood pressure
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high diastolic blood pressure
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 5A
Description: Top 50 taxa associated with all high metal exposures and cardiometabolic factors
Abundance in Group 1: increased abundance in High diastolic blood pressure
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 5A
Description: Top 50 taxa associated with all high metal exposures and cardiometabolic factors
Abundance in Group 1: decreased abundance in High diastolic blood pressure
Revision editor(s): Anne-mariesharp
Experiment 26
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-diabetic
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Diabetic
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants diagnosed with T2DM (Type 2 Diabetes Mellitus)
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 5A
Description: Top 50 taxa associated with all high metal exposures and cardiometabolic factors
Abundance in Group 1: increased abundance in Diabetic
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 5A
Description: Top 50 taxa associated with all high metal exposures and cardiometabolic factors
Abundance in Group 1: decreased abundance in Diabetic
Revision editor(s): Anne-mariesharp
Experiment 27
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Non-hypertensive
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Hypertensive
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with hypertension
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 5A
Description: Top 50 taxa associated with all high metal exposures and cardiometabolic factors
Abundance in Group 1: increased abundance in Hypertensive
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 5A
Description: Top 50 taxa associated with all high metal exposures and cardiometabolic factors
Abundance in Group 1: decreased abundance in Hypertensive
Revision editor(s): Anne-mariesharp
Experiment 28
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low body mass index (BMI)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High body mass index (BMI)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high body mass index (BMI)
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 5A
Description: Top 50 taxa associated with all high metal exposures and cardiometabolic factors
Abundance in Group 1: increased abundance in High body mass index (BMI)
| NCBI | Quality Control | Links |
|---|---|---|
| Dialister | ||
| Dialister invisus | ||
| [Clostridium] innocuum | ||
| Lachnospiraceae UCG 010Lachnospiraceae UCG 010 | ||
| Tyzzerella | ||
| Thomasclavelia | ||
| Clostridium | ||
| Peptococcus |
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 5A
Description: Top 50 taxa associated with all high metal exposures and cardiometabolic factors
Abundance in Group 1: decreased abundance in High body mass index (BMI)
Revision editor(s): Anne-mariesharp
Experiment 29
Subjects
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low glucose result
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High glucose result
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants with high glucose result
Lab analysis
Statistical Analysis
Signature 1
Source: Figure 5A
Description: Top 50 taxa associated with all high metal exposures and cardiometabolic factors
Abundance in Group 1: increased abundance in High glucose result
| NCBI | Quality Control | Links |
|---|---|---|
| Akkermansia muciniphila | ||
| Megamonas funiformis | ||
| Paraprevotella | ||
| Syntrophococcus | ||
| Prevotella_9 copriPrevotella_9 copri | ||
| UCG 005UCG 005 | ||
| Thomasclavelia | ||
| Clostridium | ||
| Peptococcus |
Revision editor(s): Anne-mariesharp
Signature 2
Source: Figure 5A
Description: Top 50 taxa associated with all high metal exposures and cardiometabolic factors
Abundance in Group 1: decreased abundance in High glucose result
Revision editor(s): Anne-mariesharp
Contents
- 1 Experiment 1
- 2 Experiment 2
- 3 Experiment 3
- 4 Experiment 4
- 5 Experiment 5
- 6 Experiment 6
- 7 Experiment 7
- 8 Experiment 8
- 9 Experiment 9
- 10 Experiment 10
- 11 Experiment 11
- 12 Experiment 12
- 13 Experiment 13
- 14 Experiment 14
- 15 Experiment 15
- 16 Experiment 16
- 17 Experiment 17
- 18 Experiment 18
- 19 Experiment 19
- 20 Experiment 20
- 21 Experiment 21
- 22 Experiment 22
- 23 Experiment 23
- 24 Experiment 24
- 25 Experiment 25
- 26 Experiment 26
- 27 Experiment 27
- 28 Experiment 28
- 29 Experiment 29
