Dynamic microbe and molecule networks in a mouse model of colitis-associated colorectal cancer/Experiment 1
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Reviewed Marked as Reviewed by Svetlana up on 2025-1-3
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Colorectal carcinoma
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Control group
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- AOS/DSS (Azoxymethane/Dextran Sodium Sulphate)-treated group
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Mice treated with AOM/DSS to induce chronic colitis and colorectal cancer
- Group 0 sample size Number of subjects in the control (unexposed) group
- 10
- Group 1 sample size Number of subjects in the case (exposed) group
- 11
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- log transformation
- Statistical test
- edgeR
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Signature 1
Needs review
Source: Table S2, Fig. 4B
Description: Differential OTUs between control mice and AOM/DSS-treated mice, showing significant microbial shifts associated with colorectal cancer progression.
Abundance in Group 1: increased abundance in AOS/DSS (Azoxymethane/Dextran Sodium Sulphate)-treated group
Revision editor(s): Wendy640, KateRasheed, WikiWorks
Signature 2
Needs review
Source: Table S2, Fig. 4B
Description: Differential OTUs between control mice and AOM/DSS-treated mice, showing significant microbial shifts associated with colorectal cancer progression.
Abundance in Group 1: decreased abundance in AOS/DSS (Azoxymethane/Dextran Sodium Sulphate)-treated group
Revision editor(s): Wendy640, KateRasheed, WikiWorks
