Cutaneous microbiome effects of fluticasone propionate cream and adjunctive bleach baths in childhood atopic dermatitis/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Claregrieve1 on 2022/09/1
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Skin of body
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- healthy control
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- atopic dermatitis
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- child between the age of 3 months-5 years with moderate to severe atopic dermatitis defined as an investigator’s global assessment (IGA) score of 3 or 4 (0–4 scale)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 11
- Group 1 sample size Number of subjects in the case (exposed) group
- 21
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 2 weeks
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Statistical test
- Kruskall-Wallis
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
Signature 1
Needs review
Source: Figure 7a, 7b
Description: Differential microbial abundance between baseline atopic dermatitis lesional sites versus control skin
Abundance in Group 1: increased abundance in atopic dermatitis
| NCBI | Quality Control | Links |
|---|---|---|
| Bacilli | ||
| Staphylococcus |
Revision editor(s): Claregrieve1, WikiWorks
Signature 2
Needs review
Source: Figure 7a, 7b
Description: Differential microbial abundance between baseline atopic dermatitis lesional sites versus control skin
Abundance in Group 1: decreased abundance in atopic dermatitis
| NCBI | Quality Control | Links |
|---|---|---|
| Actinomycetes | ||
| Alphaproteobacteria | ||
| Bacteroidia | ||
| Betaproteobacteria | ||
| Clostridia | ||
| Coriobacteriia | ||
| Erysipelotrichia | ||
| Rubrobacteria | ||
| Verrucomicrobiia | ||
| Lautropia | ||
| Cupriavidus |
Revision editor(s): Claregrieve1, WikiWorks
