Subgingival microbiota dysbiosis in systemic lupus erythematosus: association with periodontal status/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-2-24
Subjects
- Location of subjects
- Brazil
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Subgingival dental plaque Subgingival plaque,Subgingival dental plaque,subgingival dental plaque
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Systemic lupus erythematosus Disease, Libman-Sacks,disseminated lupus erythematosus,excess LMW-DNA,excess lymphocyte low molecular weight DNA,LIBMAN SACKS DIS,Libman Sacks Disease,Libman-Sacks Disease,lupus,Lupus Erythematosus Disseminatus,Lupus Erythematosus, Systemic,lupus erythematosus, systemic,SLE,SLE - lupus erythematosus, systemic,systemic lupus erythematosus,systemic lupus erythematosus (disease),Systemic lupus erythematosus
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Control with Non-periodontitis (C-NCP)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Systemic Lupus Erythematosus with Non-periodontitis (SLE-NCP)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Systemic Lupus Erythematosus (SLE) patients with Non-periodontitis (NCP)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 24
- Group 1 sample size Number of subjects in the case (exposed) group
- 17
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 3 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- raw counts
- Statistical test
- DESeq2
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Matched on Factors on which subjects have been matched on in a case-control study
- age, sex
Alpha Diversity
- Chao1 Abundance-based estimator of species richness
- increased
- Richness Number of species
- increased
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-2-24
Source: Figures 5a, 5b
Description: OTUs with different relative abundance in control subjects and SLE patients in non-periodontitis.
Abundance in Group 1: increased abundance in Systemic Lupus Erythematosus with Non-periodontitis (SLE-NCP)
| NCBI | Quality Control | Links |
|---|---|---|
| unclassified Lachnospiraceae A IR009unclassified Lachnospiraceae A IR009 |
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-2-24
Source: Figures 5a, 5b
Description: OTUs with different relative abundance in control subjects and SLE samples in non-periodontitis.
Abundance in Group 1: decreased abundance in Systemic Lupus Erythematosus with Non-periodontitis (SLE-NCP)
| NCBI | Quality Control | Links |
|---|---|---|
| Mogibacterium | ||
| Sphingomonas |
