Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases/Experiment 2

From BugSigDB


Reviewed Marked as Reviewed by KateRasheed on 2025-6-25

Curated date: 2025/04/26

Curator: Aiyshaaaa

Revision editor(s): Aiyshaaaa, UtibeIta, Victoria

Subjects

Location of subjects
United States of America
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Crohn's disease Colitis, Granulomatous,CROHN DIS,Crohn Disease,Crohn disease,Crohn's associated gastritis,Crohn's disease,Crohn's disease of colon,Crohn's disease of large bowel,CROHNS DIS,Crohns Disease,Enteritis, Granulomatous,Enteritis, Regional,Gastritis Associated with Crohn Disease,Gastritis Associated with Crohn's Disease,granulomatous colitis,Ileitis, Regional,Ileitis, Terminal,Ileocolitis,pediatric Crohn's disease,regional enteritis,crohn disease,crohn's disease
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Non Remitters Crohn's disease (CD)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Remitters Crohn's disease (CD)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Comparison of Crohn's Disease (CD) patients who did not achieve remission and Crohn's Disease (CD) patients who achieved remission between baseline and follow-up of week 14
Group 0 sample size Number of subjects in the control (unexposed) group
24
Group 1 sample size Number of subjects in the case (exposed) group
10

Lab analysis

Sequencing type
WMS
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
T-Test
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes

Alpha Diversity

Richness Number of species
increased

Signature 1

Reviewed Marked as Reviewed by KateRasheed on 2025-6-25

Curated date: 2025/04/26

Curator: Aiyshaaaa

Revision editor(s): Aiyshaaaa, UtibeIta

Source: Fig-3c

Description: Log2FC of species that represented significant change at week 14 follow-up in comparison with baseline sample of CD divided into remission and non-remission groups

Abundance in Group 1: decreased abundance in Remitters Crohn's disease (CD)

NCBI Quality ControlLinks
Bifidobacterium longum
Eggerthella
Mediterraneibacter gnavus
Roseburia inulinivorans
Veillonella parvula

Revision editor(s): Aiyshaaaa, UtibeIta