Gut Microbiome Function Predicts Response to Anti-integrin Biologic Therapy in Inflammatory Bowel Diseases/Experiment 3

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Reviewed Marked as Reviewed by KateRasheed on 2025-6-25

Curated date: 2025/04/26

Curator: Aiyshaaaa

Revision editor(s): Aiyshaaaa, UtibeIta, Victoria

Subjects

Location of subjects
United States of America
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Ulcerative colitis colitis ulcerative,Colitis, Ulcerative,Left-sided ulcerative (chronic) colitis,Left-sided ulcerative colitis,left-sided ulcerative colitis,Other ulcerative colitis,Other ulcerative colitis (disorder),UC - ulcerative colitis,ulcerative colitis,ulcerative colitis (disease),ulcerative colitis (disorder),Ulcerative colitis, unspecified,ULCERATVE COLITIS UNSPCF,Ulcerative colitis
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Non-Remitters Ulcerative Colitis (UC)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Remitters Ulcerative Colitis (UC)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Comparison of Ulcerative Colitis (UC) patients who achieved remission and Ulcerative Colitis (UC) patients who did not achieve remission between baseline and follow-up of week 14
Group 0 sample size Number of subjects in the control (unexposed) group
17
Group 1 sample size Number of subjects in the case (exposed) group
11

Lab analysis

Sequencing type
WMS
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
T-Test
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes

Alpha Diversity

Richness Number of species
unchanged

Signature 1

Reviewed Marked as Reviewed by KateRasheed on 2025-6-25

Curated date: 2025/04/26

Curator: Aiyshaaaa

Revision editor(s): Aiyshaaaa, UtibeIta

Source: Fig-3c

Description: Log2FC of species that represented significant change at week 14 follow-up in comparison with baseline sample of UC divided into remission and non-remission groups

Abundance in Group 1: decreased abundance in Remitters Ulcerative Colitis (UC)

NCBI Quality ControlLinks
Streptococcus salivarius

Revision editor(s): Aiyshaaaa, UtibeIta