A yeast fermentate improves gastrointestinal discomfort and constipation by modulation of the gut microbiome: results from a randomized double-blind placebo-controlled pilot trial/Experiment 8
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-4-23
Subjects
- Location of subjects
- Belgium
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Chronic constipation Chronic constipation,Infrequent bowel movements,chronic constipation
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- EpiCor Severe subgroup V1(Visit 1)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- EpiCor Severe subgroup V2(Visit 2)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- A subgroup of participants with severe symptoms of gastrointestinal discomfort and constipation at visit 2 (3-weeks after treatment) who received the corresponding testing product (EpiCor fermentate)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 27
- Group 1 sample size Number of subjects in the case (exposed) group
- 27
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 2 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V5-V6
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- ANOVA
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.1
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-4-23
Source: Additional file 8
Description: Microbial taxa fold-changes (V2/V1) in Severe subgroup (EpiCor)
Abundance in Group 1: increased abundance in EpiCor Severe subgroup V2(Visit 2)
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides | ||
| Prevotella | ||
| Anaerostipes |
Revision editor(s): Anne-mariesharp
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-4-23
Source: Additional file 8
Description: Microbial taxa fold-changes (V2/V1) in Severe subgroup (EpiCor)
Abundance in Group 1: decreased abundance in EpiCor Severe subgroup V2(Visit 2)
| NCBI | Quality Control | Links |
|---|---|---|
| Alistipes | ||
| Faecalibacterium | ||
| Oscillospiraceae | ||
| Rikenellaceae |
Revision editor(s): Anne-mariesharp
