Adhesive Bifidobacterium Induced Changes in Cecal Microbiome Alleviated Constipation in Mice

From BugSigDB
Needs review
study design
Citation
PMID PubMed identifier for scientific articles.
DOI Digital object identifier for electronic documents.
URI
Authors
Wang L, Chen C, Cui S, Lee YK, Wang G, Zhao J, Zhang H, Chen W
Journal
Frontiers in microbiology
Year
2019
Keywords:
Bifidobacterium, SCFAs, adhesion properties, constipation, gut microbiota
Constipation, which seriously affects living quality of people, is a common gastrointestinal disease. The engagement of the intestinal flora in the development of symptoms of constipation has been frequently hypothesized. In this study, constipated mice induced by loperamide were used to investige the alleviation of constipation by Bifidobacteria. Bifidobacteria was sorted out according to their adhesive properties into two groups. One group combined multiple strains of Bifidobacterium with adhesion property (CMB1), the other combined multiple strains of Bifidobacterium without adhesion property (CMB2). It was found that CMB1 can alleviate constipation more efficiently by improving the water, propionate and butyrate content in feces, and overall gastrointestinal transit time. Meanwhile, from the perspective of fecal microbiota, CMB1 alleviated constipation mainly by increasing the relative abundances of genera (Bifidobacterium, Lactobacillus, and Prevotella) associated with rapid bowel movement. From the perspective of cecal microbiota, CMB1 alleviated constipation mainly by increasing the relative abundances of genera Lactobacillus, Bacteroides, unclassified S24-7, Dorea, Ruminococcus, Coprococcus, and Rikenella, and decreasing the relative abundances of genera Oscillospira, Odoribacter and Unclassified F16, which are associated with methane production and colonic transit. Overall, changes of microbiota in caecum by CMB1 reflect the stage of constipation in mice more comprehensively than that in feces.

Experiment 1


Needs review

Curated date: 2025/04/07

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Mus musculus
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Constipation Constipation,Costiveness,Dyschezia,constipation
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Control ( Constipation mice without treatment )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks
Group 0 sample size Number of subjects in the control (unexposed) group
8
Group 1 sample size Number of subjects in the case (exposed) group
8

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
log transformation
Statistical test
ANOVA
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05

Alpha Diversity

Chao1 Abundance-based estimator of species richness
increased
Richness Number of species
increased
Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
increased

Signature 1

Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 3

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Bifidobacterium

Revision editor(s): Joiejoie

Experiment 2


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Alpha Diversity

Chao1 Abundance-based estimator of species richness
unchanged
Richness Number of species
unchanged
Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
unchanged

Signature 1

Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 3

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in CMB2 (Constipation mice treated with CMB with no adhesion properties)

NCBI Quality ControlLinks
Bifidobacterium

Revision editor(s): Joiejoie

Experiment 3


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Alpha Diversity

Chao1 Abundance-based estimator of species richness
unchanged
Richness Number of species
unchanged
Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
unchanged

Signature 1

Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 3

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Odoribacter

Revision editor(s): Joiejoie

Experiment 4


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Alpha Diversity

Chao1 Abundance-based estimator of species richness
unchanged
Richness Number of species
unchanged
Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
unchanged

Signature 1

Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 3

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in CMB2 (Constipation mice treated with CMB with no adhesion properties)

NCBI Quality ControlLinks
Odoribacter

Revision editor(s): Joiejoie

Experiment 5


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Control ( Constipation mice without treatment )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 + Normal (Healthy mice)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
The CMB1 group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks, while the normal group was given 0.25 mL of normal saline (NS) using intragastric administration once a day for 17 days

Lab analysis

Statistical Analysis

Alpha Diversity

Chao1 Abundance-based estimator of species richness
unchanged
Richness Number of species
unchanged
Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
unchanged

Signature 1

Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 3

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in CMB1 + Normal (Healthy mice)

NCBI Quality ControlLinks
Parabacteroides

Revision editor(s): Joiejoie

Experiment 6


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 name Corresponds to the case (exposed) group for case-control studies
All groups ( Normal, Control, CMB2 )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
These groups were given 0.25 mL normal saline (NS) using intragastric administration once a day for 17 days, while the CMB2 group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks.

Lab analysis

Statistical Analysis

Alpha Diversity

Chao1 Abundance-based estimator of species richness
unchanged
Richness Number of species
unchanged
Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
unchanged

Signature 1

Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 3

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in All groups ( Normal, Control, CMB2 )

NCBI Quality ControlLinks
Lactobacillus

Revision editor(s): Joiejoie

Experiment 7


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Control ( Constipation mice without treatment )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 + Normal (Healthy mice)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
The CMB1 group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks, while the normal group was given 0.25 mL of normal saline (NS) using intragastric administration once a day for 17 days

Lab analysis

Statistical Analysis

Alpha Diversity

Chao1 Abundance-based estimator of species richness
unchanged
Richness Number of species
unchanged
Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
unchanged

Signature 1

Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 3

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB1 + Normal (Healthy mice)

NCBI Quality ControlLinks
Lactobacillus

Revision editor(s): Joiejoie

Experiment 8


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Alpha Diversity

Chao1 Abundance-based estimator of species richness
unchanged
Richness Number of species
unchanged
Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
unchanged

Signature 1

Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 3

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Clostridium

Revision editor(s): Joiejoie

Experiment 9


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Alpha Diversity

Chao1 Abundance-based estimator of species richness
unchanged
Richness Number of species
unchanged
Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
unchanged

Signature 1

Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 3

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Clostridium

Revision editor(s): Joiejoie

Experiment 10


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/12

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 4

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
unclassified Lachnospiraceae

Revision editor(s): Joiejoie

Experiment 11


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/12

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 4

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB2 (Constipation mice treated with CMB with no adhesion properties)

NCBI Quality ControlLinks
unclassified Lachnospiraceae

Revision editor(s): Joiejoie

Experiment 12


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/12

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 4

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Oscillibacter

Revision editor(s): Joiejoie

Experiment 13


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/12

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 4

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB2 (Constipation mice treated with CMB with no adhesion properties)

NCBI Quality ControlLinks
Oscillibacter

Revision editor(s): Joiejoie

Experiment 14


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/12

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 4

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Ruminococcus

Revision editor(s): Joiejoie

Experiment 15


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/12

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 4

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB2 (Constipation mice treated with CMB with no adhesion properties)

NCBI Quality ControlLinks
Ruminococcus

Revision editor(s): Joiejoie

Experiment 16


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/12

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 4

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Sporobacter

Revision editor(s): Joiejoie

Experiment 17


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/12

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 4

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB2 (Constipation mice treated with CMB with no adhesion properties)

NCBI Quality ControlLinks
Sporobacter

Revision editor(s): Joiejoie

Experiment 18


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/12

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 4

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Coprobacillus

Revision editor(s): Joiejoie

Experiment 19


Needs review

Curated date: 2025/04/08

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/12

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 4

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB2 (Constipation mice treated with CMB with no adhesion properties)

NCBI Quality ControlLinks
Coprobacillus

Revision editor(s): Joiejoie

Experiment 20


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 5

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Turicibacter

Revision editor(s): Joiejoie

Experiment 21


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 5

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB2 (Constipation mice treated with CMB with no adhesion properties)

NCBI Quality ControlLinks
Turicibacter

Revision editor(s): Joiejoie

Experiment 22


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 5

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
unclassified Helicobacteraceae

Revision editor(s): Joiejoie

Experiment 23


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 5

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in CMB2 (Constipation mice treated with CMB with no adhesion properties)

NCBI Quality ControlLinks
unclassified Helicobacteraceae

Revision editor(s): Joiejoie

Experiment 24


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 5

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Anaeroplasma

Revision editor(s): Joiejoie

Experiment 25


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 5

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in CMB2 (Constipation mice treated with CMB with no adhesion properties)

NCBI Quality ControlLinks
Anaeroplasma

Revision editor(s): Joiejoie

Experiment 26


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 5

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Prevotella

Revision editor(s): Joiejoie

Experiment 27


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 5

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB2 (Constipation mice treated with CMB with no adhesion properties)

NCBI Quality ControlLinks
Prevotella

Revision editor(s): Joiejoie

Experiment 28


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 5

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Alistipes

Revision editor(s): Joiejoie

Experiment 29


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 5

Description: Relative abundance (%) of fecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB2 (Constipation mice treated with CMB with no adhesion properties)

NCBI Quality ControlLinks
Alistipes

Revision editor(s): Joiejoie

Experiment 30


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 6

Description: Relative abundance (%) of caecal microbial taxa at the genus level in constipated mice fed CMB.

Abundance in Group 1: increased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Bifidobacterium

Revision editor(s): Joiejoie

Experiment 31


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Experiment 32


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Normal ( Healthy mice )
Group 1 name Corresponds to the case (exposed) group for case-control studies
Control ( Constipation mice without treatment )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was given 0.25 mL of normal saline (NS) using intragastric administration once a day for 17 days.

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 6

Description: Relative abundance (%) of caecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in Control ( Constipation mice without treatment )

NCBI Quality ControlLinks
Adlercreutzia

Revision editor(s): Joiejoie

Experiment 33


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Control ( Constipation mice without treatment )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 6

Description: Relative abundance (%) of caecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Bacteroides

Revision editor(s): Joiejoie

Experiment 34


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 6

Description: Relative abundance (%) of caecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in CMB2 (Constipation mice treated with CMB with no adhesion properties)

NCBI Quality ControlLinks
Bacteroides

Revision editor(s): Joiejoie

Experiment 35


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Normal ( Healthy mice )
Group 1 name Corresponds to the case (exposed) group for case-control studies
Control ( Constipation mice without treatment )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was given 0.25 mL of normal saline (NS) using intragastric administration once a day for 17 days.

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 6

Description: Relative abundance (%) of caecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in Control ( Constipation mice without treatment )

NCBI Quality ControlLinks
Parabacteroides

Revision editor(s): Joiejoie

Experiment 36


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Control ( Constipation mice without treatment )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 + CMB2
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1 and CMB2, respectively, daily for 2 weeks.
Group 1 sample size Number of subjects in the case (exposed) group
16

Lab analysis

Statistical Analysis

Experiment 37


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Normal + Control + CMB1 ( All others )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks
Group 0 sample size Number of subjects in the control (unexposed) group
24
Group 1 sample size Number of subjects in the case (exposed) group
8

Lab analysis

Statistical Analysis

Experiment 38


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 6

Description: Relative abundance (%) of caecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Unclassified S24-7Unclassified S24-7

Revision editor(s): Joiejoie

Experiment 39


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Control ( Constipation mice without treatment )
Group 0 sample size Number of subjects in the control (unexposed) group
8

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 6

Description: Relative abundance (%) of caecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: decreased abundance in CMB1 ( Constipation mice treated with CMB with adhesion properties )

NCBI Quality ControlLinks
Odoribacter

Revision editor(s): Joiejoie

Experiment 40


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Source: Fig. 6

Description: Relative abundance (%) of caecal microbial taxa at the genus level in constipated mice fed CMB

Abundance in Group 1: increased abundance in CMB2 (Constipation mice treated with CMB with no adhesion properties)

NCBI Quality ControlLinks
Odoribacter

Revision editor(s): Joiejoie

Experiment 41


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Normal ( Healthy mice )
Group 1 name Corresponds to the case (exposed) group for case-control studies
Control + CMB1
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This normal group was given 0.25 mL of normal saline (NS) using intragastric administration once a day for 17 days, while the CMB1 group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks.
Group 1 sample size Number of subjects in the case (exposed) group
16

Lab analysis

Statistical Analysis

Experiment 42


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks
Group 1 sample size Number of subjects in the case (exposed) group
8

Lab analysis

Statistical Analysis

Experiment 43


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Normal + Control
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks
Group 0 sample size Number of subjects in the control (unexposed) group
16

Lab analysis

Statistical Analysis

Experiment 44


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Experiment 45


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Control ( Constipation mice without treatment )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks
Group 0 sample size Number of subjects in the control (unexposed) group
8

Lab analysis

Statistical Analysis

Experiment 46


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Normal ( Healthy mice )
Group 1 name Corresponds to the case (exposed) group for case-control studies
Control ( Constipation mice without treatment )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was given 0.25 mL of normal saline (NS) using intragastric administration once a day for 17 days.

Lab analysis

Statistical Analysis

Experiment 47


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Control ( Constipation mice without treatment )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Experiment 48


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB2 (Constipation mice treated with CMB with no adhesion properties)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks

Lab analysis

Statistical Analysis

Experiment 49


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Normal + Control + CMB2 ( All others )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 ( Constipation mice treated with CMB with adhesion properties )
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1, respectively, daily for 2 weeks
Group 0 sample size Number of subjects in the control (unexposed) group
24

Lab analysis

Statistical Analysis

Experiment 50


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Normal + CMB1
Group 1 name Corresponds to the case (exposed) group for case-control studies
Control + CMB2
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This control group was given 0.25 mL of normal saline (NS) using intragastric administration once a day for 17 days, while the CMB2 group was intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB2, respectively, daily for 2 weeks.
Group 0 sample size Number of subjects in the control (unexposed) group
16
Group 1 sample size Number of subjects in the case (exposed) group
16

Lab analysis

Statistical Analysis

Experiment 51


Needs review

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Control ( Constipation mice without treatment )
Group 1 name Corresponds to the case (exposed) group for case-control studies
CMB1 + CMB2
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
The CMB1 and CMB2 groups were intragastrically administered 0.25 mL of normal saline solution containing 4 × 1010 CFU/mL CMB1 or CMB2, respectively, daily for 2 weeks.
Group 0 sample size Number of subjects in the control (unexposed) group
8

Lab analysis

Statistical Analysis

Experiment 52


incomplete

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Not specified
Group 1 name Corresponds to the case (exposed) group for case-control studies
Not specified
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Not specified
Group 0 sample size Number of subjects in the control (unexposed) group
Not specified
Group 1 sample size Number of subjects in the case (exposed) group
Not specified

Lab analysis

Statistical Analysis

Experiment 53


incomplete

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 54


incomplete

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 55


incomplete

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 56


incomplete

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 57


incomplete

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 58


incomplete

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 59


incomplete

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 60


incomplete

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 61


incomplete

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 62


incomplete

Curated date: 2025/04/09

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 63


incomplete

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 64


incomplete

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 65


incomplete

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 66


incomplete

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 67


incomplete

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 68


incomplete

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 69


incomplete

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 70


incomplete

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 71


incomplete

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 72


incomplete

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Experiment 73


incomplete

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Normal + Control + BMC2
Group 1 name Corresponds to the case (exposed) group for case-control studies
C-Normal + C-Control + C-CBM1

Lab analysis

Statistical Analysis

Experiment 74


incomplete

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
C-Control + C-CBM1
Group 1 name Corresponds to the case (exposed) group for case-control studies
C-CBM2

Lab analysis

Statistical Analysis

Experiment 75


incomplete

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
BMC1 + BMC2
Group 1 name Corresponds to the case (exposed) group for case-control studies
C-Normal

Lab analysis

Statistical Analysis

Experiment 76


Needs review

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
C-Normal
Group 1 name Corresponds to the case (exposed) group for case-control studies
BMC1 + BMC2

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/16

Curator: Mautin

Revision editor(s): Mautin

Source: Figure 9A

Description: The genus-level comparison of fecal samples and caecum content samples.

Abundance in Group 1: increased abundance in BMC1 + BMC2

NCBI Quality ControlLinks
Anaeroplasma

Revision editor(s): Mautin

Experiment 77


Needs review

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
All others
Group 1 name Corresponds to the case (exposed) group for case-control studies
BMC1 + C-CBM1

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/16

Curator: Mautin

Revision editor(s): Mautin

Source: Figure 9B

Description: The genus-level comparison of fecal samples and caecum content samples

Abundance in Group 1: increased abundance in BMC1 + C-CBM1

NCBI Quality ControlLinks
Bacteroides

Revision editor(s): Mautin

Experiment 78


Needs review

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
BMC1
Group 1 name Corresponds to the case (exposed) group for case-control studies
BMC2 + C-Normal + C-Control

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/16

Curator: Mautin

Revision editor(s): Mautin

Source: Figure 9C

Description: The genus-level comparison of fecal samples and caecum content samples.

Abundance in Group 1: decreased abundance in BMC2 + C-Normal + C-Control

NCBI Quality ControlLinks
Bifidobacterium

Revision editor(s): Mautin

Experiment 79


Needs review

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Normal + Control + BMC2
Group 1 name Corresponds to the case (exposed) group for case-control studies
C-Normal

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/16

Curator: Mautin

Revision editor(s): Mautin

Source: Figure 9D

Description: The genus-level comparison of fecal samples and caecum content samples.

Abundance in Group 1: increased abundance in C-Normal

NCBI Quality ControlLinks
Clostridium

Revision editor(s): Mautin

Experiment 80


Needs review

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
C-Normal
Group 1 name Corresponds to the case (exposed) group for case-control studies
Normal + BMC2

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/16

Curator: Mautin

Revision editor(s): Mautin

Source: Figure 9E

Description: The genus-level comparison of fecal samples and caecum content samples.

Abundance in Group 1: decreased abundance in Normal + BMC2

NCBI Quality ControlLinks
Dorea.Dorea.

Revision editor(s): Mautin

Experiment 81


Needs review

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
C-CBM2
Group 1 name Corresponds to the case (exposed) group for case-control studies
C-Normal + C-Control + C-CBM1

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/16

Curator: Mautin

Revision editor(s): Mautin

Source: Figure 10 A

Description: The genus-level comparison of fecal samples and caecum content samples.

Abundance in Group 1: increased abundance in C-Normal + C-Control + C-CBM1

NCBI Quality ControlLinks
unclassified Helicobacteraceae

Revision editor(s): Mautin

Experiment 82


incomplete

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
C-Normal + C-Control
Group 1 name Corresponds to the case (exposed) group for case-control studies
C-CBM2

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/17

Curator: Mautin

Revision editor(s): Mautin

Source: Table 10 J

Description: The genus-level comparison of fecal samples and caecum content samples.

Abundance in Group 1: decreased abundance in C-CBM2

NCBI Quality ControlLinks
Odoribacter

Revision editor(s): Mautin

Experiment 83


Needs review

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Normal + Control + BMC1 + BMC2
Group 1 name Corresponds to the case (exposed) group for case-control studies
C-Normal + C-Control + C-CBM1

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/16

Curator: Mautin

Revision editor(s): Mautin

Source: Figure 11 A

Description: The genus-level comparison of fecal samples and caecum content samples.

Abundance in Group 1: increased abundance in C-Normal + C-Control + C-CBM1

NCBI Quality ControlLinks
Oscillospira

Revision editor(s): Mautin

Experiment 84


Needs review

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
C-Normal + C-CBM1
Group 1 name Corresponds to the case (exposed) group for case-control studies
BMC1 + BMC2

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/16

Curator: Mautin

Revision editor(s): Mautin

Source: Figure 11 B

Description: The genus-level comparison of fecal samples and caecum content samples.

Abundance in Group 1: decreased abundance in BMC1 + BMC2

NCBI Quality ControlLinks
Oscillospira

Revision editor(s): Mautin

Experiment 85


Needs review

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
All others
Group 1 name Corresponds to the case (exposed) group for case-control studies
C-Normal

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/16

Curator: Mautin

Revision editor(s): Mautin

Source: Figure 11 C

Description: The genus-level comparison of fecal samples and caecum content samples.

Abundance in Group 1: increased abundance in C-Normal

NCBI Quality ControlLinks
Parabacteroides

Revision editor(s): Mautin

Experiment 86


Needs review

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Normal + Control + BMCI + BMC2
Group 1 name Corresponds to the case (exposed) group for case-control studies
C-Normal + C-Control

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/16

Curator: Mautin

Revision editor(s): Mautin

Source: Figure 11 D

Description: The genus-level comparison of fecal samples and caecum content samples.

Abundance in Group 1: increased abundance in C-Normal + C-Control

NCBI Quality ControlLinks
Rikenella

Revision editor(s): Mautin

Experiment 87


Needs review

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
C-Normal + C-Control
Group 1 name Corresponds to the case (exposed) group for case-control studies
BMC2

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/16

Curator: Mautin

Revision editor(s): Mautin

Source: Figure 11 E

Description: The genus-level comparison of fecal samples and caecum content samples

Abundance in Group 1: decreased abundance in BMC2

NCBI Quality ControlLinks
Rikenella

Revision editor(s): Mautin

Experiment 88


Needs review

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
All others
Group 1 name Corresponds to the case (exposed) group for case-control studies
C-Control + C-CBM1

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/16

Curator: Mautin

Revision editor(s): Mautin

Source: Figure 11 F

Description: The genus-level comparison of fecal samples and caecum content samples.

Abundance in Group 1: increased abundance in C-Control + C-CBM1

NCBI Quality ControlLinks
Ruminococcus

Revision editor(s): Mautin

Experiment 89


Needs review

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
C-Control + C-CBM1
Group 1 name Corresponds to the case (exposed) group for case-control studies
Normal + Control + BMC1 + BMC2

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/15

Curator: Mautin

Revision editor(s): Mautin

Source: Figure 11 G

Description: The genus-level comparison of fecal samples and caecum content samples

Abundance in Group 1: decreased abundance in Normal + Control + BMC1 + BMC2

NCBI Quality ControlLinks
Ruminococcus

Revision editor(s): Mautin

Experiment 90


Needs review

Curated date: 2025/04/10

Curator: Joiejoie

Revision editor(s): Joiejoie, Mautin

Differences from previous experiment shown

Subjects

Group 0 name Corresponds to the control (unexposed) group for case-control studies
Normal + Control + BMCI + BMC2
Group 1 name Corresponds to the case (exposed) group for case-control studies
C-Control + C-CBM1 + C-CBM2

Lab analysis

Statistical Analysis

Signature 1

Needs review

Curated date: 2025/04/15

Curator: Mautin

Revision editor(s): Mautin

Source: Figure 11 H

Description: The genus-level comparison of fecal samples and caecum content samples.

Abundance in Group 1: increased abundance in C-Control + C-CBM1 + C-CBM2

NCBI Quality ControlLinks
Akkermansia.Akkermansia.

Revision editor(s): Mautin