Changes in the vaginal microbiota associated with primary ovarian failure/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2024-6-17
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Vaginal fluid Vaginal discharge,Vaginal secretion,Vaginal fluid,vaginal fluid
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Acquired primary ovarian failure acquired premature ovarian failure,acquired primary ovarian failure,Acquired primary ovarian failure
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Primary ovarian failure (POF)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Women of reproductive age with follicular failure
- Group 0 sample size Number of subjects in the control (unexposed) group
- 29
- Group 1 sample size Number of subjects in the case (exposed) group
- 22
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 3 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
- Chao1 Abundance-based estimator of species richness
- increased
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- increased
- Richness Number of species
- increased
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2024-6-17
Source: Figure 2a
Description: Differential genera in vaginal microbiota in patients with primary ovarian failure (POF) compared to control group
Abundance in Group 1: increased abundance in Primary ovarian failure (POF)
Revision editor(s): Ndruscilla, Scholastica, WikiWorks
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2024-6-17
Source: Figure 2a
Description: Differential genera in vaginal microbiota in patients with primary ovarian failure (POF) compared to control group
Abundance in Group 1: decreased abundance in Primary ovarian failure (POF)
| NCBI | Quality Control | Links |
|---|---|---|
| Lactobacillus | ||
| Brevundimonas | ||
| Parvimonas | ||
| Roseburia | ||
| Ochrobactrum | ||
| Atopobium | ||
| Lachnospiraceae incertae sedis |
Revision editor(s): Ndruscilla, Scholastica, WikiWorks
