Comparative Studies of the Gut Microbiota in the Offspring of Mothers With and Without Gestational Diabetes

Study information

EditHistoryDelete

Flag for review

Your review change was submittedAdd a new Experiment

• Quality control
  • Retracted paper
  • Contamination issues suspected
  • Batch effect issues suspected
  • Uncontrolled confounding suspected
  • Results are suspect (various reasons)
  • Apply tags

    Tags applied

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

study design

cross-sectional observational, not case-control

Citation

PMID PubMed identifier for scientific articles.

33194786

DOI Digital object identifier for electronic documents.

https://doi.org/10.3389/fcimb.2020.536282

URI

https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2020.536282/full

Authors

Crusell MKW, Hansen TH, Nielsen T, Allin KH, Rühlemann MC, Damm P, Vestergaard H, Rørbye C, Jørgensen NR, Christiansen OB, Heinsen FA, Franke A, Hansen T, Lauenborg J, Pedersen O

Journal

Frontiers in cellular and infection microbiology

Year

2020

Keywords:

bacterial genera, gestational diabetes, gut microbiota, infancy, maternal glycaemic traits

Background: Offspring of mothers with gestational diabetes mellitus (GDM) have increased risk of developing metabolic disorders as they grow up. Microbial colonization of the newborn gut and environmental exposures affecting the configuration of the gut microbiota during infancy have been linked to increased risk of developing disease during childhood and adulthood. In a convenience sample, we examined whether the intestinal tract of children born to mothers with GDM is differentially colonized in early life compared to offspring of mothers with normal gestational glucose regulation. Secondly, we examined whether any such difference persists during infancy, thus potentially conferring increased risk of developing metabolic disease later in life. Methods: Fecal samples were collected from children of mothers with (n = 43) and without GDM (n = 82) during the first week of life and again at an average age of 9 months. The gut microbiota was characterized by 16S rRNA gene amplicon sequencing (V1-V2). Differences in diversity and composition according to maternal GDM status were assessed, addressing potential confounding by mode of delivery, perinatal antibiotics treatment, feeding and infant sex. Results: Children of mothers with GDM were featured by a differential composition of the gut microbiota, both during the first week of life and at 9 months, at higher taxonomic and OTU levels. Sixteen and 15 OTUs were differentially abundant after correction for multiple testing during the first week of life and at 9 months, respectively. Two OTUs remained differentially abundant after adjustment for potential confounders both during the first week of life and at 9 months. Richness (OTU) was decreased in neonates born to mothers with GDM; however, at 9 months no difference in richness was observed. There was no difference in Shannon's diversity or Pielou's evenness at any timepoint. Longitudinally, we detected differential changes in the gut microbiota composition from birth to infancy according to GDM status. Conclusion: Differences in glycaemic regulation in late pregnancy is linked with relatively modest variation in the gut microbiota composition of the offspring during the first week of life and 9 months after birth.

Experiment 1

Empty strings are not accepted.

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/10/08

Curator:

Revision editor(s):

Subjects

Location of subjects

Denmark

Host species Species from which microbiome was sampled. Contact us to have more species added.

Homo sapiens

Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology

Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Maternal diabetes

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Normoglycaemic group

Group 1 name Corresponds to the case (exposed) group for case-control studies

Gestational diabetes mellitus (GDM) group

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM).

Group 0 sample size Number of subjects in the control (unexposed) group

72

Group 1 sample size Number of subjects in the case (exposed) group

34

Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)

2 months

Lab analysis

Sequencing type

16S

16S variable region One or more hypervariable region(s) of the bacterial 16S gene

V1-V2

Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance

Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).

relative abundances

Statistical test

LEfSe

Significance threshold p-value or FDR threshold used for differential abundance testing (if any)

0.05

MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?

No

LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool

2

Alpha Diversity

Pielou Quantifies how equal the community is numerically

unchanged

Shannon Estimator of species richness and species evenness: more weight on species richness

unchanged

Richness Number of species

decreased

Signature 1

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/10/08

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, WikiWorks

Source: FIGURE 4 (A)

Description: Taxonomic biomarkers of gestational diabetes in gut microbiota of newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM)

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Carnobacteriaceae
Isobaculum
Turicibacter

Revision editor(s): AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/10/09

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, WikiWorks

Source: FIGURE 4 (A)

Description: Taxonomic biomarkers of gestational diabetes in gut microbiota of newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM)

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Ethanoligenens
Megasphaera
Micrococcaceae
Negativicutes
Prevotella
Prevotellaceae
Rothia
Selenomonadales
Subdoligranulum
Veillonella
Veillonellaceae

Revision editor(s): AishatBolarinwa, WikiWorks

Experiment 2

Empty strings are not accepted.

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/10/08

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Infants (9 months of age) born to mothers with gestational diabetes mellitus (GDM).

Group 0 sample size Number of subjects in the control (unexposed) group

64

Group 1 sample size Number of subjects in the case (exposed) group

32

Lab analysis

Statistical Analysis

Alpha Diversity

Pielou Quantifies how equal the community is numerically

unchanged

Shannon Estimator of species richness and species evenness: more weight on species richness

unchanged

Richness Number of species

unchanged

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/10/09

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Source: FIGURE 4 (B)

Description: Taxonomic biomarkers of gestational diabetes in gut microbiota of infants (9 months of life) born to mothers with gestational diabetes mellitus (GDM)

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Pseudomonadota

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Signature 2

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/10/09

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Source: FIGURE 4 (B)

Description: Taxonomic biomarkers of gestational diabetes in gut microbiota of infants (9 months of life) born to mothers with gestational diabetes mellitus (GDM)

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Actinomycetaceae
Actinomycetota
Alteromonadales
Collinsella
Dorea
Propionibacteriaceae
Propionibacterium
Shewanella
Shewanellaceae
Subdoligranulum

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Experiment 3

Empty strings are not accepted.

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/10

Curator: Aleru Divine

Revision editor(s): Aleru Divine, WikiWorks

Differences from previous experiment shown

Subjects

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM)

Group 0 sample size Number of subjects in the control (unexposed) group

72

Group 1 sample size Number of subjects in the case (exposed) group

34

Lab analysis

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).

raw counts

Statistical test

DESeq2

MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?

Yes

LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool

Not specified

Alpha Diversity

Pielou Quantifies how equal the community is numerically

unchanged

Shannon Estimator of species richness and species evenness: more weight on species richness

unchanged

Richness Number of species

decreased

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/10

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S3

Description: OTUs differentially abundant in Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM).

Abundance in Group 1: increased abundance in Gestational diabetes mellitus (GDM) group

NCBI	Quality Control	Links
Escherichia/Shigella sp.
Staphylococcus
Clostridium XVIIIClostridium XVIII

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/10

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S3

Description: OTUs differentially abundant in Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM).

Abundance in Group 1: decreased abundance in Gestational diabetes mellitus (GDM) group

NCBI	Quality Control	Links
Bacteroides
Citrobacter
Collinsella
Faecalibacterium
Halomonas
Phascolarctobacterium
Prevotella
Propionibacterium
Shewanella
Streptococcus
Veillonella

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Experiment 4

Empty strings are not accepted.

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/10

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Infants (9 months of age) born to mothers with gestational diabetes mellitus (GDM)

Group 0 sample size Number of subjects in the control (unexposed) group

64

Group 1 sample size Number of subjects in the case (exposed) group

32

Lab analysis

Statistical Analysis

Alpha Diversity

Pielou Quantifies how equal the community is numerically

unchanged

Shannon Estimator of species richness and species evenness: more weight on species richness

unchanged

Richness Number of species

unchanged

Signature 1

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S3

Description: OTUs differentially abundant in Infants (9 months of life) born to mothers with gestational diabetes mellitus (GDM).

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Faecalibacterium

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S3

Description: OTUs differentially abundant in Infants (9 months of life) born to mothers with gestational diabetes mellitus (GDM).

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Erysipelotrichaceae incertae sedis
Escherichia/Shigella sp.
Megasphaera
Paraprevotella
Phascolarctobacterium
Prevotella
Rothia
Streptococcus
Veillonella

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Experiment 5

Empty strings are not accepted.

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/10

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM).

Group 0 sample size Number of subjects in the control (unexposed) group

72

Group 1 sample size Number of subjects in the case (exposed) group

34

Lab analysis

Statistical Analysis

Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment

mode of birth

Alpha Diversity

Pielou Quantifies how equal the community is numerically

unchanged

Shannon Estimator of species richness and species evenness: more weight on species richness

unchanged

Richness Number of species

decreased

Signature 1

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S4

Description: OTUs differentially abundant in Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) adjusted for mode of delivery (vaginal vs. cesarean section).

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Escherichia/Shigella sp.
Streptococcus
Veillonella
Clostridium XVIIIClostridium XVIII

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S4

Description: OTUs differentially abundant in Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) adjusted for mode of delivery (vaginal vs. cesarean section).

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Clostridium
Collinsella
Faecalibacterium
Halomonas
Propionibacterium
Shewanella
Staphylococcus
Veillonella

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Experiment 6

Empty strings are not accepted.

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/10

Curator: Aleru Divine

Revision editor(s): Aleru Divine, WikiWorks

Differences from previous experiment shown

Subjects

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Infants (9 months of age) born to mothers with gestational diabetes mellitus (GDM).

Group 0 sample size Number of subjects in the control (unexposed) group

64

Group 1 sample size Number of subjects in the case (exposed) group

32

Lab analysis

Statistical Analysis

Alpha Diversity

Pielou Quantifies how equal the community is numerically

unchanged

Shannon Estimator of species richness and species evenness: more weight on species richness

unchanged

Richness Number of species

unchanged

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S4

Description: OTUs differentially abundant in Infants (9 months of life) born to mothers with gestational diabetes mellitus (GDM) adjusted for mode of delivery (vaginal vs. cesarean section).

Abundance in Group 1: increased abundance in Gestational diabetes mellitus (GDM) group

NCBI	Quality Control	Links
Faecalibacterium
Streptococcus

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S4

Description: OTUs differentially abundant in Infants (9 months of life) born to mothers with gestational diabetes mellitus (GDM) adjusted for mode of delivery (vaginal vs. cesarean section).

Abundance in Group 1: decreased abundance in Gestational diabetes mellitus (GDM) group

NCBI	Quality Control	Links
Escherichia/Shigella sp.
Megasphaera
Paraprevotella
Parasutterella
Prevotella
Rothia
Streptococcus
Sutterella
Veillonella
Clostridium XIClostridium XI

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Experiment 7

Empty strings are not accepted.

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/10

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM).

Group 0 sample size Number of subjects in the control (unexposed) group

72

Group 1 sample size Number of subjects in the case (exposed) group

34

Lab analysis

Statistical Analysis

Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment

antibiotic therapy

Alpha Diversity

Pielou Quantifies how equal the community is numerically

unchanged

Shannon Estimator of species richness and species evenness: more weight on species richness

unchanged

Richness Number of species

decreased

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S5

Description: OTUs differentially abundant in Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) adjusted for perinatal antibiotic treatment (treated vs. untreated).

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Clostridium XVIIIClostridium XVIII

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S5

Description: OTUs differentially abundant in Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) adjusted for perinatal antibiotic treatment (treated vs. untreated).

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Collinsella
Veillonella

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Experiment 8

Empty strings are not accepted.

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/10

Curator: Aleru Divine

Revision editor(s): Aleru Divine, WikiWorks

Differences from previous experiment shown

Subjects

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Infants (9 months of age) born to mothers with gestational diabetes mellitus (GDM).

Group 0 sample size Number of subjects in the control (unexposed) group

64

Group 1 sample size Number of subjects in the case (exposed) group

32

Lab analysis

Statistical Analysis

Alpha Diversity

Pielou Quantifies how equal the community is numerically

unchanged

Shannon Estimator of species richness and species evenness: more weight on species richness

unchanged

Richness Number of species

unchanged

Signature 1

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S5

Description: OTUs differentially abundant in Infants (9 months of life) born to mothers with gestational diabetes mellitus (GDM) adjusted for perinatal antibiotic treatment (treated vs. untreated).

Abundance in Group 1: increased abundance in Gestational diabetes mellitus (GDM) group

NCBI	Quality Control	Links
Alistipes
Blautia
Faecalibacterium

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S5

Description: OTUs differentially abundant in Infants (9 months of life) born to mothers with gestational diabetes mellitus (GDM) adjusted for perinatal antibiotic treatment (treated vs. untreated).

Abundance in Group 1: decreased abundance in Gestational diabetes mellitus (GDM) group

NCBI	Quality Control	Links
Escherichia/Shigella sp.
Prevotella
Rothia
Streptococcus
Veillonella

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Experiment 9

Empty strings are not accepted.

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/10

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM).

Group 0 sample size Number of subjects in the control (unexposed) group

72

Group 1 sample size Number of subjects in the case (exposed) group

34

Lab analysis

Statistical Analysis

Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment

sex

Alpha Diversity

Pielou Quantifies how equal the community is numerically

unchanged

Shannon Estimator of species richness and species evenness: more weight on species richness

unchanged

Richness Number of species

decreased

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S6

Description: OTUs differentially abundant in Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) adjusted for sex of the child.

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Bacteroides
Klebsiella
Neisseria
Parabacteroides
Pseudocitrobacter
Staphylococcus
Streptococcus
Sutterella
Clostridium XVIIIClostridium XVIII

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S6

Description: OTUs differentially abundant in Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) adjusted for sex of the child.

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Bacteroides
Citrobacter
Collinsella
Faecalibacterium
Haemophilus
Holdemanella
Intestinibacter
Phascolarctobacterium
Propionibacterium

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Experiment 10

Empty strings are not accepted.

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/10

Curator: Aleru Divine

Revision editor(s): Aleru Divine, WikiWorks

Differences from previous experiment shown

Subjects

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Infants (9 months of age) born to mothers with gestational diabetes mellitus (GDM).

Group 0 sample size Number of subjects in the control (unexposed) group

64

Group 1 sample size Number of subjects in the case (exposed) group

32

Lab analysis

Statistical Analysis

Alpha Diversity

Pielou Quantifies how equal the community is numerically

unchanged

Shannon Estimator of species richness and species evenness: more weight on species richness

unchanged

Richness Number of species

unchanged

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S6

Description: OTUs differentially abundant in Infants (9 months of life) born to mothers with gestational diabetes mellitus (GDM) adjusted for sex of the child.

Abundance in Group 1: increased abundance in Gestational diabetes mellitus (GDM) group

NCBI	Quality Control	Links
Alistipes
Ethanoligenens
Faecalibacterium
Ruminococcus
Streptococcus

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S6

Description: OTUs differentially abundant in Infants (9 months of life) born to mothers with gestational diabetes mellitus (GDM) adjusted for sex of the child.

Abundance in Group 1: decreased abundance in Gestational diabetes mellitus (GDM) group

NCBI	Quality Control	Links
Collinsella
Escherichia/Shigella sp.
Megasphaera
Sutterella

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Experiment 11

Empty strings are not accepted.

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/10

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Lab analysis

Statistical Analysis

Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment

feeding practices

Alpha Diversity

Pielou Quantifies how equal the community is numerically

unchanged

Shannon Estimator of species richness and species evenness: more weight on species richness

unchanged

Richness Number of species

unchanged

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S7

Description: OTUs differentially abundant in infants (9 months of age) born to mothers with gestational diabetes mellitus (GDM) adjusted for feeding.

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Faecalibacterium
Ruminococcus
Streptococcus

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/11

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S7

Description: OTUs differentially abundant in infants (9 months of age) born to mothers with gestational diabetes mellitus (GDM) adjusted for feeding.

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Actinomyces
Clostridium
Collinsella
Enterococcus
Escherichia/Shigella sp.
Paraprevotella
Pluralibacter
Prevotella
Rothia
Streptococcus
Veillonella

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Experiment 12

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Disposition index measurement insulin disposition index measurement,Disposition index measurement,disposition index measurement

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Lower Tertile (low disposition index)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Upper Tertile (high disposition index)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) with with higher maternal disposition index.

Group 0 sample size Number of subjects in the control (unexposed) group

Not specified

Group 1 sample size Number of subjects in the case (exposed) group

Not specified

Lab analysis

Statistical Analysis

Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment

Not specified

Signature 1

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/13

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S8

Description: Operational taxonomic units in newborns (1 week of life) associated with maternal glycaemic traits (disposition index) unadjusted for maternal pre-pregnancy BMI.

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Bacteroides
Clostridium
Collinsella
Intestinibacter
Parabacteroides
Rothia
Staphylococcus
Streptococcus
Sutterella

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/13

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S8

Description: Operational taxonomic units in newborns (1 week of life) associated with maternal glycaemic traits (disposition index) unadjusted for maternal pre-pregnancy BMI.

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Escherichia/Shigella sp.
Haemophilus
Klebsiella
Lachnospiraceae incertae sedis
Lactobacillus
Phascolarctobacterium
Sutterella
Veillonella
Clostridium XlVaClostridium XlVa

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Experiment 13

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Fasting blood glucose measurement fasting blood glucose level,fasting glucose-related traits,fasting plasma glucose,Fasting blood glucose measurement,fasting blood glucose measurement

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Lower Tertile (low fasting plasma glucose)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Upper Tertile (high fasting plasma glucose)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) with higher maternal fasting plasma glucose.

Lab analysis

Statistical Analysis

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-18

Curated date: 2024/11/13

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S8

Description: Operational taxonomic units in newborns (1 week of life) associated with maternal glycaemic traits (fasting plasma glucose) unadjusted for maternal pre-pregnancy BMI.

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Escherichia/Shigella sp.
Sutterella
Clostridium XVIIIClostridium XVIII

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-18

Curated date: 2024/11/13

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S8

Description: Operational taxonomic units in newborns (1 week of life) associated with maternal glycaemic traits (fasting plasma glucose) unadjusted for maternal pre-pregnancy BMI.

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Bifidobacterium

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Experiment 14

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Glucose measurement glucose level,Glucose measurement,glucose measurement

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Lower Tertile (low stimulated 2-h plasma glucose level)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Upper Tertile (high stimulated 2-h plasma glucose level)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) with higher maternal stimulated 2-h plasma glucose level.

Lab analysis

Statistical Analysis

Signature 1

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/13

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S8

Description: Operational taxonomic units in newborns (1 week of life) associated with maternal glycaemic traits (stimulated 2-h plasma glucose level) unadjusted for maternal pre-pregnancy BMI.

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Lactobacillus
Sutterella
Veillonella

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/13

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S8

Description: Operational taxonomic units in newborns (1 week of life) associated with maternal glycaemic traits (stimulated 2-h plasma glucose level) unadjusted for maternal pre-pregnancy BMI.

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Bacteroides
Bilophila
Collinsella
Erysipelotrichaceae incertae sedis
Faecalibacterium
Prevotella
Propionibacterium
Streptococcus

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Experiment 15

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator: Aleru Divine

Revision editor(s): Aleru Divine, WikiWorks

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Insulin sensitivity measurement insulin sensitivity test,Insulin sensitivity measurement,insulin sensitivity measurement

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Lower Tertile (low insulin sensitivity index)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Upper Tertile (high insulin sensitivity index)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) with higher maternal insulin sensitivity index.

Lab analysis

Statistical Analysis

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S8

Description: Operational taxonomic units in newborns (1 week of life) associated with maternal glycaemic traits (insulin sensitivity index) unadjusted for maternal pre-pregnancy BMI.

Abundance in Group 1: increased abundance in Upper Tertile (high insulin sensitivity index)

NCBI	Quality Control	Links
Clostridium
Veillonella

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Table S8

Description: Operational taxonomic units in newborns (1 week of life) associated with maternal glycaemic traits (insulin sensitivity index) unadjusted for maternal pre-pregnancy BMI.

Abundance in Group 1: decreased abundance in Upper Tertile (high insulin sensitivity index)

NCBI	Quality Control	Links
Bacteroides
Lachnospiraceae incertae sedis
Pseudocitrobacter
Staphylococcus
Streptococcus
Sutterella
Veillonella
Clostridium XVIaClostridium XVIa

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Experiment 16

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-18

Curated date: 2024/11/13

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Glucose measurement glucose level,Glucose measurement,glucose measurement

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Lower Tertile (low stimulated 2-h plasma glucose level)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Upper Tertile (high stimulated 2-h plasma glucose level)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) with higher maternal stimulated 2-h plasma glucose level.

Lab analysis

Statistical Analysis

Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment

body mass index

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-18

Curated date: 2024/11/13

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Source: Figure S8

Description: Operational taxonomic units in newborns (1 week of life) associated with maternal glycaemic traits (stimulated 2-h plasma glucose level) adjusted for maternal pre-pregnancy BMI.

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Streptococcus

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Experiment 17

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Disposition index measurement insulin disposition index measurement,Disposition index measurement,disposition index measurement

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Lower Tertile (low disposition index)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Upper Tertile (high disposition index)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Infants (9 months of age) born to mothers with gestational diabetes mellitus (GDM) with with higher maternal disposition index.

Lab analysis

Statistical Analysis

Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment

Not specified

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/14

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Source: Table S9

Description: Operational taxonomic units in infants (9 months of age) associated with maternal glycaemic traits (disposition index), unadjusted for pre-pregnancy BMI.

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Actinobacillus
Collinsella
Escherichia/Shigella sp.
Parabacteroides
Paraprevotella
Prevotella
Romboutsia
Streptococcus
Veillonella

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Signature 2

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/14

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Source: Table S9

Description: Operational taxonomic units in infants (9 months of age) associated with maternal glycaemic traits (disposition index), unadjusted for pre-pregnancy BMI.

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Alistipes
Bacteroides
Blautia
Dorea
Escherichia/Shigella sp.
Ethanoligenens
Faecalibacterium
Isobaculum
Romboutsia
Roseburia
Turicibacter

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Experiment 18

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Fasting blood glucose measurement fasting blood glucose level,fasting glucose-related traits,fasting plasma glucose,Fasting blood glucose measurement,fasting blood glucose measurement

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Lower Tertile (low fasting plasma glucose)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Upper Tertile (high fasting plasma glucose)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Infants (9 months of age) born to mothers with gestational diabetes mellitus (GDM) with higher maternal fasting plasma glucose.

Lab analysis

Statistical Analysis

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/14

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Source: Table S9

Description: Operational taxonomic units in infants (9 months of age) associated with maternal glycaemic traits (fasting plasma glucose), unadjusted for pre-pregnancy BMI.

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Alistipes
Faecalibacterium
Lactobacillus
Streptococcus

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Signature 2

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/14

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Source: Table S9

Description: Operational taxonomic units in infants (9 months of age) associated with maternal glycaemic traits (fasting plasma glucose), unadjusted for pre-pregnancy BMI.

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Actinomyces
Anaerostipes
Anaerotruncus
Bifidobacterium
Collinsella
Coprococcus
Enterococcus
Megasphaera
Paraprevotella
Prevotella
Sutterella
clostridium xviiiclostridium xviii

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Experiment 19

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Glucose measurement glucose level,Glucose measurement,glucose measurement

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Lower Tertile (low stimulated 2-h plasma glucose level)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Upper Tertile (high stimulated 2-h plasma glucose level)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Infants (9 months of age) born to mothers with gestational diabetes mellitus (GDM) with higher maternal stimulated 2-h plasma glucose level.

Lab analysis

Statistical Analysis

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-18

Curated date: 2024/11/14

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Source: Table S9

Description: Operational taxonomic units in infants (9 months of age) associated with maternal glycaemic traits (stimulated 2-h plasma glucose level), unadjusted for pre-pregnancy BMI.

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Alistipes
Enterococcus
Porphyromonas

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Signature 2

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-18

Curated date: 2024/11/14

Curator: AishatBolarinwa

Revision editor(s): WikiWorks, Folakunmi, Aleru Divine, AishatBolarinwa

Source: Table S9

Description: Operational taxonomic units in infants (9 months of age) associated with maternal glycaemic traits (stimulated 2-h plasma glucose level), unadjusted for pre-pregnancy BMI.

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Clostridium
Roseburia
Veillonella

Revision editor(s): WikiWorks, Folakunmi, Aleru Divine, AishatBolarinwa

Experiment 20

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Insulin sensitivity measurement insulin sensitivity test,Insulin sensitivity measurement,insulin sensitivity measurement

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Lower Tertile (low insulin sensitivity index)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Upper Tertile (high insulin sensitivity index)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) with higher maternal insulin sensitivity index.

Lab analysis

Statistical Analysis

Signature 1

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/14

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Source: Table S9

Description: Operational taxonomic units in infants (9 months of age) associated with maternal glycaemic traits (insulin sensitivity index), unadjusted for pre-pregnancy BMI.

Abundance in Group 1: increased abundance in Upper Tertile (high insulin sensitivity index)

NCBI	Quality Control	Links
Haemophilus
Paraprevotella
Prevotella
Streptococcus
Veillonella

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Signature 2

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/14

Curator: AishatBolarinwa

Revision editor(s): WikiWorks, Folakunmi, Aleru Divine, AishatBolarinwa

Source: Table S9

Description: Operational taxonomic units in infants (9 months of age) associated with maternal glycaemic traits (insulin sensitivity index), unadjusted for pre-pregnancy BMI.

Abundance in Group 1: decreased abundance in Upper Tertile (high insulin sensitivity index)

NCBI	Quality Control	Links
Clostridium
Enterococcus
Escherichia/Shigella sp.
Ethanoligenens
Klebsiella
Veillonella

Revision editor(s): WikiWorks, Folakunmi, Aleru Divine, AishatBolarinwa

Experiment 21

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Disposition index measurement insulin disposition index measurement,Disposition index measurement,disposition index measurement

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Lower Tertile (low disposition index)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Upper Tertile (high disposition index)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Infants (9 months of age) born to mothers with gestational diabetes mellitus (GDM) with with higher maternal disposition index.

Lab analysis

Statistical Analysis

Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment

body mass index

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-18

Curated date: 2024/11/14

Curator: AishatBolarinwa

Revision editor(s): WikiWorks, Folakunmi, Aleru Divine, AishatBolarinwa

Source: Table S9

Description: Operational taxonomic units in infants (9 months of age) associated with maternal glycaemic traits (disposition index), adjusted for pre-pregnancy BMI.

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Bacteroides
Streptococcus
Veillonella

Revision editor(s): WikiWorks, Folakunmi, Aleru Divine, AishatBolarinwa

Signature 2

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-18

Curated date: 2024/11/14

Curator: AishatBolarinwa

Revision editor(s): WikiWorks, Folakunmi, Aleru Divine, AishatBolarinwa

Source: Table S9

Description: Operational taxonomic units in infants (9 months of age) associated with maternal glycaemic traits (disposition index), adjusted for pre-pregnancy BMI.

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Granulicatella
Romboutsia

Revision editor(s): WikiWorks, Folakunmi, Aleru Divine, AishatBolarinwa

Experiment 22

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Fasting blood glucose measurement fasting blood glucose level,fasting glucose-related traits,fasting plasma glucose,Fasting blood glucose measurement,fasting blood glucose measurement

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Lower Tertile (low fasting plasma glucose)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Upper Tertile (high fasting plasma glucose)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Infants (9 months of age) born to mothers with gestational diabetes mellitus (GDM) with higher maternal fasting plasma glucose.

Lab analysis

Statistical Analysis

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-18

Curated date: 2024/11/14

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Source: Table S9

Description: Operational taxonomic units in infants (9 months of age) associated with maternal glycaemic traits (fasting plasma glucose), adjusted for pre-pregnancy BMI.

Abundance in Group 1: decreased abundance in

NCBI	Quality Control	Links
Coprococcus

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Experiment 23

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Glucose measurement glucose level,Glucose measurement,glucose measurement

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Lower Tertile (low stimulated 2-h plasma glucose level)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Upper Tertile (high stimulated 2-h plasma glucose level)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Infants (9 months of age) born to mothers with gestational diabetes mellitus (GDM) with higher maternal stimulated 2-h plasma glucose level.

Lab analysis

Statistical Analysis

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-18

Curated date: 2024/11/14

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Source: Table S9

Description: Operational taxonomic units in infants (9 months of age) associated with maternal glycaemic traits (stimulated 2-h plasma glucose level), adjusted for pre-pregnancy BMI.

Abundance in Group 1: increased abundance in Upper Tertile (high stimulated 2-h plasma glucose level)

NCBI	Quality Control	Links
Actinomyces
Faecalibacterium

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Experiment 24

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator:

Revision editor(s):

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Insulin sensitivity measurement insulin sensitivity test,Insulin sensitivity measurement,insulin sensitivity measurement

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Lower Tertile (low insulin sensitivity index)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Upper Tertile (high insulin sensitivity index)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) with higher maternal insulin sensitivity index.

Lab analysis

Statistical Analysis

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-18

Curated date: 2024/11/14

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Source: Table S9

Description: Operational taxonomic units in infants (9 months of age) associated with maternal glycaemic traits (insulin sensitivity index), adjusted for pre-pregnancy BMI.

Abundance in Group 1: increased abundance in

NCBI	Quality Control	Links
Streptococcus

Revision editor(s): AishatBolarinwa, Aleru Divine, WikiWorks

Experiment 25

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Differences from previous experiment shown

Subjects

Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology

Gestational weight gain measurement Gestational weight gain measurement,gestational weight gain measurement

Group 0 name Corresponds to the control (unexposed) group for case-control studies

Lower Tertile (low gestational weight gain)

Group 1 name Corresponds to the case (exposed) group for case-control studies

Upper Tertile (high gestational weight gain)

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Newborns (1 week of life) born to mothers with gestational diabetes mellitus (GDM) with higher gestational weight gain.

Lab analysis

Statistical Analysis

Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment

Not specified

Signature 1

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/13

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, Folakunmi, WikiWorks

Source: Table S12

Description: OTUs in newborns (1 week of life) associated with maternal gestational weight gain unadjusted for pre-pregnancy BMI

Abundance in Group 1: increased abundance in Upper Tertile (high gestational weight gain)

NCBI	Quality Control	Links
Bacteroides
Bifidobacterium
Dialister
Haemophilus
Staphylococcus
Veillonella

Revision editor(s): AishatBolarinwa, Folakunmi, WikiWorks

Signature 2

EditHistoryDelete

Mark reviewed

Your review change was submitted

Needs review

Curated date: 2024/11/13

Curator: AishatBolarinwa

Revision editor(s): WikiWorks, Folakunmi, Aleru Divine, AishatBolarinwa

Source: Table S12

Description: OTUs in newborns (1 week of life) associated with maternal gestational weight gain unadjusted for pre-pregnancy BMI

Abundance in Group 1: decreased abundance in Upper Tertile (high gestational weight gain)

NCBI	Quality Control	Links
Bacteroides
Clostridium
Collinsella
Holdemanella
Klebsiella
Neisseria
Roseburia
Sutterella

Revision editor(s): WikiWorks, Folakunmi, Aleru Divine, AishatBolarinwa

Experiment 26

EditHistoryDelete

Flag for review

Your review change was submittedDuplicate this ExperimentAdd a new Signature

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator: Aleru Divine

Revision editor(s): Aleru Divine, AishatBolarinwa, WikiWorks

Differences from previous experiment shown

Subjects

Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group

Infants (9 months of age) born to mothers with gestational diabetes mellitus (GDM) with higher gestational weight gain.

Lab analysis

Statistical Analysis

Signature 1

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, WikiWorks

Source: Table S12

Description: OTUs in Infants (9 months of age) associated with maternal gestational weight gain unadjusted for pre-pregnancy BMI

Abundance in Group 1: increased abundance in Upper Tertile (high gestational weight gain)

NCBI	Quality Control	Links
Haemophilus
Prevotella

Revision editor(s): AishatBolarinwa, WikiWorks

Signature 2

EditHistoryDelete

Flag for review

Your review change was submitted

Reviewed Marked as Reviewed by Folakunmi on 2024-11-25

Curated date: 2024/11/13

Curator: AishatBolarinwa

Revision editor(s): AishatBolarinwa, WikiWorks

Source: Table S12

Description: OTUs in Infants (9 months of age) associated with maternal gestational weight gain unadjusted for pre-pregnancy BMI

Abundance in Group 1: decreased abundance in Upper Tertile (high gestational weight gain)

NCBI	Quality Control	Links
Faecalibacterium

Revision editor(s): AishatBolarinwa, WikiWorks