Short-Chain Fatty Acid-Producing Gut Microbiota Is Decreased in Parkinson's Disease but Not in Rapid-Eye-Movement Sleep Behavior Disorder/Experiment 2
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Reviewed Marked as Reviewed by Svetlana up on 2025-1-24
Subjects
- Location of subjects
- Japan
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Sleep Disorder Disturbances, Sleep,disturbances, sleep,parasomnia,sleep disorder,Sleep Disorders,Sleep Disturbance,sleep disturbance,Sleep Disturbances,sleep disturbances,Sleep Disorder,sleep Disorder
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy Controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Rapid-eye-movement sleep behavior disorder (iRBD) patients
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients with idiopathic rapid-eye-movement sleep behavior disorder (iRBD) diagnosed according to the International Classification of Sleep Disorders Criteria-Third Edition
- Group 0 sample size Number of subjects in the control (unexposed) group
- 137
- Group 1 sample size Number of subjects in the case (exposed) group
- 26
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 1 month
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Statistical test
- ANCOM
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, body mass index, sex, constipation, proton-pump inhibitor
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-1-24
Source: Supplementary Table S4
Description: Generalized linear mixed model (GLMM) analysis to evaluate confounding factors of seven genera and two families that were significantly changed in iRBD compared to controls
Abundance in Group 1: increased abundance in Rapid-eye-movement sleep behavior disorder (iRBD) patients
| NCBI | Quality Control | Links |
|---|---|---|
| Ruminococcus 2Ruminococcus 2 | ||
| Alistipes | ||
| Akkermansia | ||
| Ruminococcaceae UCG-004Ruminococcaceae UCG-004 | ||
| Family XIII AD3011 groupFamily XIII AD3011 group | ||
| Rikenellaceae | ||
| Akkermansiaceae |
Revision editor(s): Aleru Divine, WikiWorks
