Fecal Microbiota Transplantation Modulates the Gut Flora Favoring Patients With Functional Constipation/Experiment 3
From BugSigDB
Reviewed Marked as Reviewed by KateRasheed on 2025-7-9
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Health-related quality of life measurement HRQOL,Health-related quality of life measurement,health-related quality of life measurement
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low PAC_QOL (Patient-Assessment of Constipation Quality of Life)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High PAC_QOL (Patient-Assessment of Constipation Quality of Life)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients with high Patient-Assessment of Constipation Quality of Life (PAC_QOL) score, indicating more severe constipation symptoms.
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 3 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Spearman Correlation
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Signature 1
Reviewed Marked as Reviewed by KateRasheed on 2025-7-9
Source: Figure 3B
Description: Spearman correlation analysis revealed a correlation between patients’ clinical symptoms and the significantly altered bacteria from the LEfSe analysis.
Abundance in Group 1: decreased abundance in High PAC_QOL (Patient-Assessment of Constipation Quality of Life)
| NCBI | Quality Control | Links |
|---|---|---|
| Fusicatenibacter | ||
| Paraprevotella | ||
| Coprococcus |
Revision editor(s): Anne-mariesharp
