Gut microbiota dysbiosis in Parkinson disease: A systematic review and pooled analysis/Experiment 3
From BugSigDB
Reviewed Marked as Reviewed by KateRasheed on 2025-7-9
Subjects
- Location of subjects
- China
- Finland
- Germany
- Italy
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Parkinson's disease IDIOPATHIC PARKINSON DIS,Idiopathic Parkinson Disease,Idiopathic Parkinson's Disease,IDIOPATHIC PARKINSONS DIS,Idiopathic PD,LEWY BODY PARKINSON DIS,Lewy Body Parkinson Disease,Lewy Body Parkinson's Disease,Paralysis agitans,paralysis agitans,PARKINSON DIS,PARKINSON DIS IDIOPATHIC,Parkinson disease,Parkinson Disease, Idiopathic,Parkinson syndrome,Parkinson's,Parkinson's disease,Parkinson's disease (disorder),Parkinson's disease NOS,Parkinson's disease NOS (disorder),Parkinson's Disease, Idiopathic,Parkinson's Disease, Lewy Body,Parkinson's syndrome,Parkinsonian disorder,Parkinsonism, Primary,Parkinsons,PARKINSONS DIS,PARKINSONS DIS IDIOPATHIC,PARKINSONS DIS LEWY BODY,Parkinsons disease,Primary Parkinsonism,parkinson's disease
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy Control
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Parkinson's Disease (PD) patients
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Participants were classified as Parkinson's Disease (PD) patients after the use of UK Brain Bank criteria for the diagnosis of Parkinson's Disease (PD)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 751
- Group 1 sample size Number of subjects in the case (exposed) group
- 1092
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- centered log-ratio
- Statistical test
- ANCOM-BC
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, sex
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
- Richness Number of species
- unchanged
Signature 1
Reviewed Marked as Reviewed by KateRasheed on 2025-7-9
Source: Table SE1
Description: Differentially abundant bacterial taxa identified in a sub group meta analysis with confounders controlled for age and sex
Abundance in Group 1: increased abundance in Parkinson's Disease (PD) patients
Signature 2
Reviewed Marked as Reviewed by KateRasheed on 2025-7-9
Source: Table SE1
Description: Differentially abundant bacterial taxa identified in a sub group meta analysis with confounders controlled for age and sex
Abundance in Group 1: decreased abundance in Parkinson's Disease (PD) patients
| NCBI | Quality Control | Links |
|---|---|---|
| Blautia | ||
| Butyricicoccus | ||
| Enterobacteriaceae | ||
| Faecalibacterium | ||
| Fusicatenibacter | ||
| Lachnospiraceae | ||
| Prevotella | ||
| Pseudomonadota | ||
| Roseburia |
Revision editor(s): Ese
