Altered gut microbiome composition in nontreated plaque psoriasis patients/Experiment 5
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-4-7
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Psoriasis vulgaris plaque psoriasis,Psoriasis vulgaris,psoriasis vulgaris
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Psoriasis vulgaris
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients diagnosed with Psoriasis vulgaris by two attending dermatologists.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 15
- Group 1 sample size Number of subjects in the case (exposed) group
- 32
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 6 months
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Matched on Factors on which subjects have been matched on in a case-control study
- age, body mass index, race, sex
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Richness Number of species
- unchanged
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-4-7
Source: Fig 4d
Description: Boxplot showing the difference of the relative abundance at the phylum level between psoriatic and healthy controls samples
Abundance in Group 1: increased abundance in Psoriasis vulgaris
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroidota |
Revision editor(s): Anne-mariesharp
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-4-7
Source: Fig 4d - f
Description: Boxplot showing the difference of the relative abundance at the phylum, genus and species level between psoriatic and healthy controls samples
Abundance in Group 1: decreased abundance in Psoriasis vulgaris
| NCBI | Quality Control | Links |
|---|---|---|
| Bacillota | ||
| Coprococcus | ||
| Eubacterium | ||
| Lachnospira eligens | ||
| Lachnospiraceae bacterium 8_1_57FAA | ||
| Phocaeicola coprophilus | ||
| Roseburia | ||
| Roseburia intestinalis |
Revision editor(s): Anne-mariesharp
