The gut microbiome in intravenous immunoglobulin-treated chronic inflammatory demyelinating polyneuropathy
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Quality control
- Retracted paper
- Contamination issues suspected
- Batch effect issues suspected
- Uncontrolled confounding suspected
- Results are suspect (various reasons)
- Tags applied
Experiment 1
Subjects
- Location of subjects
- Germany
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Chronic inflammatory demyelinating polyneuropathy chronic inflammatory demyelinating polyneuropathy,chronic inflammatory demyelinating polyradiculoneuropathy,CIDP,GBS,Guillain-Barre syndrome, familial,polyneuropathy, inflammatory demyelinating, acute,polyneuropathy, inflammatory demyelinating, chronic,Chronic inflammatory demyelinating polyneuropathy
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy Controls (HC)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- CIDP patients (Chronic inflammatory demyelinating polyneuropathy)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients who have been diagnosed with Chronic inflammatory demyelinating polyneuropathy
- Group 0 sample size Number of subjects in the control (unexposed) group
- 15
- Group 1 sample size Number of subjects in the case (exposed) group
- 16
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 6 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2
- Matched on Factors on which subjects have been matched on in a case-control study
- age
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
Signature 1
Source: Fig-1a and c
Description: Linear discriminant analysis (LDA) effect size of the gut microbiota of healthy subjects (HC) and chronic inflammatory demyelinating polyneuropathy (CIDP) patients of bacterial at phylum, order and family level
Abundance in Group 1: increased abundance in CIDP patients (Chronic inflammatory demyelinating polyneuropathy)
Revision editor(s): Aiyshaaaa, Svetlana up
Signature 2
Source: Fig-1a and c
Description: Linear discriminant analysis (LDA) effect size of the gut microbiota of healthy subjects (HC) and chronic inflammatory demyelinating polyneuropathy (CIDP) patients of bacterial at phylum, order and family level
Abundance in Group 1: decreased abundance in CIDP patients (Chronic inflammatory demyelinating polyneuropathy)
NCBI | Quality Control | Links |
---|---|---|
Bacteroidaceae | ||
Barnesiellaceae | ||
Marinifilaceae | ||
Rikenellaceae | ||
Pseudomonadota |
Revision editor(s): Aiyshaaaa
Experiment 2
Subjects
Lab analysis
Statistical Analysis
- Statistical test
- Mann-Whitney (Wilcoxon)
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- Not specified
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- increased
Signature 1
Source: Table-S1
Description: Relative abundances of the gut microbiota of healthy subjects (HC) and chronic inflammatory demyelinating polyneuropathy (CIDP) patients of bacterial at family and genus level
Abundance in Group 1: increased abundance in CIDP patients (Chronic inflammatory demyelinating polyneuropathy)
Revision editor(s): Aiyshaaaa