Enteric nervous system damage caused by abnormal intestinal butyrate metabolism may lead to functional constipation/Experiment 1

From BugSigDB


Reviewed Marked as Reviewed by KateRasheed on 2025-7-10

Curated date: 2025/04/17

Curator: Tosin

Revision editor(s): Tosin

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Chronic constipation Chronic constipation,Infrequent bowel movements,chronic constipation
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Group 1
Group 1 name Corresponds to the case (exposed) group for case-control studies
Group 2
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Low risk people for Functional constipation (FC) whose defecation frequency was 1 time/day
Group 0 sample size Number of subjects in the control (unexposed) group
38
Group 1 sample size Number of subjects in the case (exposed) group
360

Lab analysis

Sequencing type
WMS
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
BGISEQ-500 Sequencing

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
raw counts
Statistical test
DESeq2
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Simpson Estimator of species richness and species evenness: more weight on species evenness
unchanged

Signature 1

Reviewed Marked as Reviewed by KateRasheed on 2025-7-10

Curated date: 2025/04/17

Curator: Tosin

Revision editor(s): Tosin, Victoria

Source: Figure 1E, Table S4, Figure S3a, Figure S5e, Figure S5f

Description: Significant different bacteria genus, species among the four groups obtained via Deseq2 in the comparison between groups 1 and 2

Abundance in Group 1: increased abundance in Group 2

NCBI Quality ControlLinks
Acidaminococcus
Acidaminococcus sp. CAG:542
Akkermansia
Akkermansia muciniphila
Akkermansia muciniphila CAG:154
Alistipes sp. CAG:29
Anaerotruncus sp. CAG:528
Azospirillum
Azospirillum sp. CAG:239
Azospirillum sp. CAG:260
Bacteroides sp. CAG:927
Bifidobacterium
Bifidobacterium bifidum
Bifidobacterium longum
Bifidobacterium pseudocatenulatum
Candidatus Apopatosoma intestinale
Clostridiales bacterium VE202-14
Clostridium sp. CAG:138
Clostridium sp. CAG:217
Clostridium sp. CAG:226
Clostridium sp. CAG:302
Clostridium sp. CAG:343
Clostridium sp. CAG:349
Clostridium sp. CAG:352
Clostridium sp. CAG:417
Clostridium sp. CAG:440
Clostridium sp. CAG:492
Clostridium sp. CAG:571
Clostridium sp. CAG:62
Clostridium sp. CAG:678
Clostridium sp. CAG:780
Clostridium sp. CAG:798
Dialister invisus
Dialister succinatiphilus
Escherichia fergusonii
Eubacterium sp. CAG:202
Eubacterium sp. CAG:38
Eubacterium sp. CAG:581
Faecalibacterium sp. CAG:74
Firmicutes bacterium CAG:114
Firmicutes bacterium CAG:129
Firmicutes bacterium CAG:238
Firmicutes bacterium CAG:240
Firmicutes bacterium CAG:321
Firmicutes bacterium CAG:341
Firmicutes bacterium CAG:41
Megamonas
Megamonas hypermegale
Megamonas rupellensis
Odoribacter splanchnicus
Odoribacter splanchnicus CAG:14
Phascolarctobacterium succinatutens
Phocaeicola plebeius CAG:211
Prevotella sp. CAG:1031
Prevotella sp. CAG:255
Prevotella sp. CAG:279
Prevotella sp. CAG:485
Prevotella sp. CAG:873
Prevotella sp. CAG:891
Roseburia sp. CAG:380
Ruminococcus sp. CAG:177
Ruminococcus sp. CAG:254
Ruminococcus sp. CAG:55
Ruminococcus sp. CAG:90
Streptococcus parasanguinis
Streptococcus salivarius
Streptococcus thermophilus
Subdoligranulum sp. 4_3_54A2FAA
Succinatimonas
Succinatimonas sp. CAG:777
Sutterella sp. CAG:397
Sutterella sp. CAG:521
Sutterella wadsworthensis CAG:135
Veillonella atypica
Veillonella magna
Veillonella parvula
[Clostridium] leptum
unclassified Acidaminococcus
unclassified Akkermansia
unclassified Bifidobacterium
unclassified Enterobacter
unclassified Odoribacter
unclassified Streptococcus
unclassified Sutterella
unclassified Veillonella
Prevotella pectinovora

Revision editor(s): Tosin, Victoria

Signature 2

Reviewed Marked as Reviewed by KateRasheed on 2025-7-10

Curated date: 2025/04/17

Curator: Tosin

Revision editor(s): Tosin, Victoria

Source: Figure 1E, Table S4, Figure S3a, Figure S5e, Figure S5f

Description: Significant different bacteria genus, species among the four groups obtained via Deseq2 in the comparison between groups 1 and 2

Abundance in Group 1: decreased abundance in Group 2

NCBI Quality ControlLinks
Bacteroides graminisolvens
Bacteroides sp. CAG:98
Clostridium sp. CAG:127
Firmicutes bacterium CAG:56
Fusobacterium
Fusobacterium nucleatum
Fusobacterium ulcerans
Fusobacterium varium
Holdemanella
Holdemanella biformis
Phocaeicola massiliensis
Phocaeicola sartorii
Ruminococcus sp. CAG:254
Schaedlerella arabinosiphila
[Clostridium] clostridioforme CAG:132
unclassified Erysipelotrichaceae
Clostridium sp. ASF502Clostridium sp. ASF502

Revision editor(s): Tosin, Victoria