Ischaemic stroke patients present sex differences in gut microbiota/Experiment 1

From BugSigDB


Reviewed Marked as Reviewed by Svetlana up on 2025-4-15

Curated date: 2025/04/12

Curator: Aiyshaaaa

Revision editor(s): Aiyshaaaa

Subjects

Location of subjects
Spain
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Ischemic stroke Ischaemic stroke,Ischemic stroke,ischemic stroke
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Male IS patients (Ischemic stroke)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Female IS patients (Ischemic stroke)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Female patients who have been diagnosed with Ischemic stroke
Group 0 sample size Number of subjects in the control (unexposed) group
53
Group 1 sample size Number of subjects in the case (exposed) group
36
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
1 month

Lab analysis

Sequencing type
WMS
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
log transformation
Statistical test
Negative Binomial Regression
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes
Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
age

Alpha Diversity

Shannon Estimator of species richness and species evenness: more weight on species richness
unchanged
Chao1 Abundance-based estimator of species richness
decreased
Simpson Estimator of species richness and species evenness: more weight on species evenness
unchanged
Richness Number of species
decreased

Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-4-15

Curated date: 2025/04/12

Curator: Aiyshaaaa

Revision editor(s): Aiyshaaaa

Source: Fig-2b and Table-2

Description: Log-transformed and differential abundance of Fusobacteria (phylum to family level) in between male and female ischemic stroke patients.

Abundance in Group 1: increased abundance in Female IS patients (Ischemic stroke)

NCBI Quality ControlLinks
Fusobacteriaceae
Fusobacteriales
Fusobacteriia
Fusobacteriota

Revision editor(s): Aiyshaaaa