Oral and gut microbial biomarkers of susceptibility to respiratory tract infection in adults: A feasibility study/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-3-31
Subjects
- Location of subjects
- United Kingdom
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Saliva Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Respiratory tract infectious disease infection, respiratory tract,infections, respiratory,infections, respiratory tract,infections, upper respiratory,infections, upper respiratory tract,respiratory infection, upper,respiratory infections,respiratory tract infection,upper respiratory infections,upper respiratory tract infections,Respiratory tract infectious disease,respiratory tract infectious disease
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- healthy controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- respiratory tract infection(baseline)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- participants who acquired Respiratory Tract Infection symptoms at the baseline/start of the study
- Group 0 sample size Number of subjects in the control (unexposed) group
- 21
- Group 1 sample size Number of subjects in the case (exposed) group
- 19
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Chao1 Abundance-based estimator of species richness
- unchanged
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-3-31
Source: Figure 5
Description: Difference between microbial biomarkers in oral baseline samples from participants who acquired Respiratory Tract Infection symptoms compared to those who remained healthy.
Abundance in Group 1: increased abundance in respiratory tract infection(baseline)
| NCBI | Quality Control | Links |
|---|---|---|
| Megamonas | ||
| Megamonas sp. | ||
| Streptococcus sobrinus |
Revision editor(s): UtibeIta
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-3-31
Source: Figure 5
Description: Difference between microbial biomarkers in oral baseline samples from participants who acquired Respiratory Tract Infection symptoms compared to those who remained healthy.
Abundance in Group 1: decreased abundance in respiratory tract infection(baseline)
| NCBI | Quality Control | Links |
|---|---|---|
| Dethiosulfovibrio | ||
| Lactobacillus sp. | ||
| Ligilactobacillus salivarius | ||
| Synergistota | ||
| Verrucomicrobiota | ||
| uncultured Synergistia bacterium |
Revision editor(s): UtibeIta
