The gut microbiome and metabolites are altered and interrelated in patients with functional constipation/Experiment 8

From BugSigDB


Reviewed Marked as Reviewed by Svetlana up on 2025-4-15

Curated date: 2025/04/09

Curator: Daberechi

Revision editor(s): Daberechi, Tosin

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Chronic constipation Chronic constipation,Infrequent bowel movements,chronic constipation
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Low levels of bristol stool form scale (BSFS)
Group 1 name Corresponds to the case (exposed) group for case-control studies
High levels of bristol stool form scale (BSFS)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Patients with high levels of bristol stool form scale
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
1 month

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Spearman Correlation
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes


Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-4-15

Curated date: 2025/04/09

Curator: Daberechi

Revision editor(s): Daberechi

Source: Table S2

Description: The correlations between differential genera and clinical parameters.

Abundance in Group 1: increased abundance in High levels of bristol stool form scale (BSFS)

NCBI Quality ControlLinks
Gilliamella
ML635J_40_aquatic_groupML635J_40_aquatic_group

Revision editor(s): Daberechi

Signature 2

Reviewed Marked as Reviewed by Svetlana up on 2025-4-15

Curated date: 2025/04/09

Curator: Daberechi

Revision editor(s): Daberechi, Tosin

Source: Table S2

Description: The correlations between differential genera and clinical parameters.

Abundance in Group 1: decreased abundance in High levels of bristol stool form scale (BSFS)

NCBI Quality ControlLinks
Akkermansia
Anaerobutyricum hallii
Bacteria incertae sedis
Colidextribacter
Eubacterium coprostanoligenes
Eubacterium ruminantium
Intestinibacter
Klebsiella
Lachnoclostridium
Lachnospira
Lachnospiraceae bacterium NK4A136
Parabacteroides
UCG_002UCG_002
UCG_005UCG_005

Revision editor(s): Daberechi, Tosin