Excess fermentation and lactic acidosis as detrimental functions of the gut microbes in treatment-naive TB patients/Experiment 1
From BugSigDB
Subjects
- Location of subjects
- Russian Federation
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Pulmonary tuberculosis lung TB,lung tuberculosis,pulmonary TB,pulmonary tuberculosis,Tuberculosis, Pulmonary,Pulmonary tuberculosis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- healthy controls (HCs)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Treatment‑naïve tuberculosis (TB) patients
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- pulmonary TB as confirmed by chest radiography and a positive sputum smear or were positive for M. tuberculosis based on the GeneXpert MTB/RIF test without evidence of rifampin resistance.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 47
- Group 1 sample size Number of subjects in the case (exposed) group
- 23
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- use of anti-TB drugs within the past 30 days
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 4.5
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
Signature 1
Source: Figure 2B
Description: Taxonomic composition of the fecal microbiota of TB patients and healthy controls. Barplot depicting top bacterial species (LDA scores > 4.5) discriminating between groups.
Abundance in Group 1: increased abundance in Treatment‑naïve tuberculosis (TB) patients
Revision editor(s): Nuerteye
Signature 2
Source: Figure 2B
Description: Taxonomic composition of the fecal microbiota of TB patients and healthy controls. Barplot depicting top bacterial species (LDA scores > 4.5) discriminating between groups.
Abundance in Group 1: decreased abundance in Treatment‑naïve tuberculosis (TB) patients
Revision editor(s): Nuerteye
