Metagenomic gut microbiome analysis of Japanese patients with multiple chemical sensitivity/idiopathic environmental intolerance/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-2-27
Subjects
- Location of subjects
- Japan
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Multiple chemical sensitivity 20th century disease,chemical AIDS,environmental illness,idiopathic environmental illness,Multiple Chemical Sensitivity,multiple chemical sensitivity,total allergy syndrome,Multiple chemical sensitivity
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy Control (HC)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Multiple Chemical Sensitivity (MCS)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Japanese female patients with Multiple Chemical Sensitivity (MCS)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 24
- Group 1 sample size Number of subjects in the case (exposed) group
- 30
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 6 months
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Mann-Whitney (Wilcoxon)
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- Matched on Factors on which subjects have been matched on in a case-control study
- age, sex
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Richness Number of species
- unchanged
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-2-27
Source: Fig. 2b, Fig. 3a, Fig. 4a, Additional File Fig. S1a
Description: Relative abundances of species that differed significantly between multiple chemical sensitivity (MCS, n = 30) patients and healthy controls (HC, n = 24).
Abundance in Group 1: increased abundance in Multiple Chemical Sensitivity (MCS)
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-2-27
Source: Fig. 2a, Fig. 3b, Fig. 4b, Additional File Fig. S1b
Description: Relative abundances of species that differed significantly between multiple chemical sensitivity (MCS, n = 30) patients and healthy controls (HC, n = 24).
Abundance in Group 1: decreased abundance in Multiple Chemical Sensitivity (MCS)
