Large-scale causal analysis of gut microbiota and six common complications of diabetes: a mendelian randomization study/Experiment 7
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-3-3
Subjects
- Location of subjects
- Finland
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Hypoglycemia Hypoglycaemia,Low blood sugar,Hypoglycemia,hypoglycemia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Diabetic hypoglycemia
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients with diabetic hypoglycemia obtained from the FinnGen consortium.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 271817
- Group 1 sample size Number of subjects in the case (exposed) group
- 7332
Lab analysis
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, alcohol drinking, smoking behavior, sex, Confounders controlled for: "triglycerides levels" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.triglycerides levels, Confounders controlled for: "low-density lipoprotein levels" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.low-density lipoprotein levels, Confounders controlled for: "genotyping batch" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.genotyping batch, Confounders controlled for: "first 10 principle components" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.first 10 principle components
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-3-3
Source: Figure 5
Description: Multivariate Mendelian Randomization (MR) results: After adjusting for confounding factors, including consumption of alcoholic drinks, LDL levels, TG levels, and smoking.
Abundance in Group 1: increased abundance in Diabetic hypoglycemia
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroidia |
Revision editor(s): Aleru Divine, WikiWorks
