Peripheral neuronal activation shapes the microbiome and alters gut physiology/Experiment 5

From BugSigDB


Reviewed Marked as Reviewed by KateRasheed on 2025-4-30

Curated date: 2025/04/18

Curator: PreciousChijioke

Revision editor(s): PreciousChijioke, KateRasheed

Subjects

Location of subjects
United States of America
Host species Species from which microbiome was sampled. Contact us to have more species added.
Mus musculus
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Peripheral neuron Peripheral neuron,peripheral neuron
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Control mice on day 10
Group 1 name Corresponds to the case (exposed) group for case-control studies
ChAT+ (Choline acetyltransferase) -activated mice on day 10
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
ChAT+ (Choline acetyltransferase) -activated mice were treated with C21 ( compound 21) (3 mg/kg) administered daily for 10 consecutive days.

Lab analysis

Sequencing type
WMS
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
Not specified
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
2

Alpha Diversity

Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
decreased

Signature 1

Reviewed Marked as Reviewed by KateRasheed on 2025-4-30

Curated date: 2025/04/18

Curator: PreciousChijioke

Revision editor(s): PreciousChijioke

Source: Fig S7

Description: Gut-Associated Activation-Meditated Changes in the Fecal Microbiome

Abundance in Group 1: increased abundance in ChAT+ (Choline acetyltransferase) -activated mice on day 10

NCBI Quality ControlLinks
Akkermansia
Akkermansiaceae
Verrucomicrobiales

Revision editor(s): PreciousChijioke

Signature 2

Reviewed Marked as Reviewed by KateRasheed on 2025-4-30

Curated date: 2025/04/19

Curator: PreciousChijioke

Revision editor(s): PreciousChijioke

Source: Fig S7

Description: Gut-Associated Activation-Meditated Changes in the Fecal Microbiome

Abundance in Group 1: decreased abundance in ChAT+ (Choline acetyltransferase) -activated mice on day 10

NCBI Quality ControlLinks
Adlercreutzia
Alistipes
Anaerofustis
Anaerotruncus
Barnesiella
Barnesiellaceae
Bifidobacteriaceae
Bifidobacteriales
Bifidobacterium
Blautia
Burkholderiales
Candidatus Stoquefichus
Cellulomonadaceae
Cellulomonas
Clostridiaceae
Clostridium
Coprobacter
Coprococcus
Dorea
Eisenbergiella
Enterococcaceae
Enterococcus
Erysipelotrichaceae
Erysipelotrichales
Eubacteriaceae
Eubacteriales
Eubacterium
Faecalicatena
Faecalitalea
Flavobacteriales
Intestinimonas
Lachnoclostridium
Lachnospiraceae
Lawsonia
Marinilabiliales
Marvinbryantia
Micrococcales
Oscillibacter
Oscillospiraceae
Parabacteroides
Parasutterella
Prevotella
Prevotellaceae
Pseudoflavonifractor
Rikenella
Rikenellaceae
Ruminiclostridium
Ruminococcus
Ruthenibacterium
Sellimonas
Spirochaetaceae
Spirochaetales
Sutterellaceae
Tannerellaceae
Treponema
Tyzzerella
Varicellovirus

Revision editor(s): PreciousChijioke