Peripheral neuronal activation shapes the microbiome and alters gut physiology/Experiment 8
From BugSigDB
Reviewed Marked as Reviewed by KateRasheed on 2025-4-30
Curated date: 2025/04/30
Curator: PreciousChijioke
Revision editor(s): PreciousChijioke, KateRasheed
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Peripheral neuron Peripheral neuron,peripheral neuron
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Control mice on day 10
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- ChAT+ (Choline acetyltransferase) -activated mice on day 10
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- ChAT+ (Choline acetyltransferase) -activated mice were treated with C21 ( compound 21) (3 mg/kg) administered daily for 10 consecutive days.
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- T-Test
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Alpha Diversity
- Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
- decreased
Signature 1
Reviewed Marked as Reviewed by KateRasheed on 2025-4-30
Source: Fig 2N
Description: Gut-associated ChAT+ and TH+ neuronal activation alters the gut microbiome
Abundance in Group 1: increased abundance in ChAT+ (Choline acetyltransferase) -activated mice on day 10
| NCBI | Quality Control | Links |
|---|---|---|
| Akkermansia |
Revision editor(s): PreciousChijioke
