Association between environmental phthalates exposure and gut microbiota and metabolome in dementia with Lewy bodies/Experiment 1
From BugSigDB
Needs review
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Lewy body dementia dementia with Lewy bodies,dementia, Lewy body,diffuse Lewy body disease,diffuse Lewy body disease with gaze palsy,DLB,Lewy body dementia,Lewy body disease,Lewy body variant of Alzheimer disease,Senile dementia of the Lewy body type,lewy body dementia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Healthy controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- DLB patients
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients diagnosed with Dementia with Lewy bodies
- Group 0 sample size Number of subjects in the control (unexposed) group
- 45
- Group 1 sample size Number of subjects in the case (exposed) group
- 43
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- excluded those with antibiotic use in the past 1 month
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Signature 1
Needs review
Source: Figure 5
Description: Taxa enriched in DLB patients
Abundance in Group 1: increased abundance in DLB patients
| NCBI | Quality Control | Links |
|---|---|---|
| Alistipes putredinis | ||
| Bacteroides intestinalis | ||
| Bacteroides stercoris | ||
| Faecalibacterium prausnitzii | ||
| Oscillibacter valericigenes | ||
| Phocaeicola vulgatus | ||
| Ruminococcus |
Revision editor(s): Kristin.abraham
Signature 2
Needs review
Source: Figure 5
Description: Taxa depleted in DLB patients
Abundance in Group 1: decreased abundance in DLB patients
| NCBI | Quality Control | Links |
|---|---|---|
| Barnesiella intestinihominis | ||
| Bifidobacterium breve | ||
| Bifidobacterium longum | ||
| Prevotella |
Revision editor(s): Kristin.abraham
