Differences in salivary microbiome among children with tonsillar hypertrophy and/or adenoid hypertrophy/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-1-10
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Saliva Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Hypertrophy Hypertrophy,hypertrophy
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Control + Adenotonsillar hypertrophy (ATH) group
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Tonsillar hypertrophy (TH)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- These are children diagnosed with severe tonsillar hypertrophy (TH). It was divided into larger tonsillar hypertrophy group THL (n = 26) and smaller tonsillar hypertrophy group THS (n = 20)
- Group 0 sample size Number of subjects in the control (unexposed) group
- 45
- Group 1 sample size Number of subjects in the case (exposed) group
- 46
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 3 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2.0
- Matched on Factors on which subjects have been matched on in a case-control study
- age
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-1-10
Source: FIG 2A-B
Description: Linear discriminant analysis (LDA) scores showing significant taxonomic differences among the Tonsillar hypertrophy (TH) group and ATH + control groups.
Abundance in Group 1: increased abundance in Tonsillar hypertrophy (TH)
Revision editor(s): Rahila, KateRasheed, WikiWorks
