Fecal microbiota transplantation from patients with polycystic ovary syndrome induces metabolic disorders and ovarian dysfunction in germ-free mice/Experiment 4

From BugSigDB


Reviewed Marked as Reviewed by KateRasheed on 2025-5-9

Curated date: 2025/05/02

Curator: PreciousChijioke

Revision editor(s): PreciousChijioke

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Mus musculus
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Insulin resistance Drug resistance to insulin (disorder),Insulin resistance,insulin resistance
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Low HOMAIR (insulin resistance index) of colonized GF mice
Group 1 name Corresponds to the case (exposed) group for case-control studies
High HOMAIR (insulin resistance index) of colonized GF mice
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
The High HOMA-IR (insulin resistance index) of colonized GF mice.

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No


Signature 1

Reviewed Marked as Reviewed by KateRasheed on 2025-5-9

Curated date: 2025/05/02

Curator: PreciousChijioke

Revision editor(s): PreciousChijioke

Source: Fig. 5

Description: Heatmap of Spearman’s correlations between key bacteria of mice on Day 28 (genus level) and clinical factor HOMAIR, insulin resistance index.

Abundance in Group 1: increased abundance in High HOMAIR (insulin resistance index) of colonized GF mice

NCBI Quality ControlLinks
Candidatus Scatocola
Catenibacillus
Clostridium_AClostridium_A
Mediterranibacter_A_155507Mediterranibacter_A_155507

Revision editor(s): PreciousChijioke

Signature 2

Reviewed Marked as Reviewed by KateRasheed on 2025-5-9

Curated date: 2025/05/02

Curator: PreciousChijioke

Revision editor(s): PreciousChijioke

Source: Fig. 5

Description: Heatmap of Spearman’s correlations between key bacteria of mice on Day 28 (genus level) and clinical factor HOMAIR, insulin resistance index.

Abundance in Group 1: decreased abundance in High HOMAIR (insulin resistance index) of colonized GF mice

NCBI Quality ControlLinks
Clostridium_AQClostridium_AQ
Hungatella_A_128155Hungatella_A_128155
Klebsiella_724518Klebsiella_724518

Revision editor(s): PreciousChijioke