Appearance of green tea compounds in plasma following acute green tea consumption is modulated by the gut microbiome in mice/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-4-16
Subjects
- Location of subjects
- United States of America
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Diet measurement Diet measurement,diet measurement
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low complexity microbiome (LCM) mice
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Human colonized (HU) mice
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Mice were orally administered 200 μL of human fecal slurry (100 mg stool homogenized in 1 mL reduced phosphate-buffered saline [PBS]) at 4 weeks of age.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 9
- Group 1 sample size Number of subjects in the case (exposed) group
- 20
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- log transformation
- Statistical test
- ANCOM-BC
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Faith Phylogenetic diversity, takes into account phylogenetic distance of all taxa identified in a sample
- increased
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-4-16
Source: Within results text (Taxonomic composition of fecal microbiomes),Figure 2
Description: Taxonomic composition between Low Complexity Microbiome and Humanized Microbiome mice.
Abundance in Group 1: decreased abundance in Human colonized (HU) mice
| NCBI | Quality Control | Links |
|---|---|---|
| Candidatus Epulonipiscium | ||
| Turicibacter | ||
| unclassified Peptostreptococcaceae |
Revision editor(s): Ese, Ameenatoloko
