Fecal Microbiota Transplantation (FMT) From a Human at Low Risk for Alzheimer's Disease Improves Short-Term Recognition Memory and Increases Neuroinflammation in a 3xTg AD Mouse Model/Experiment 4
From BugSigDB
Needs review
Subjects
- Location of subjects
- Switzerland
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Mus musculus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Cecum mucosa Caecum mucosa,Caecum mucosa of organ,Caecum mucous membrane,Caecum organ mucosa,Cecal mucosa,Cecum mucosa of organ,Cecum mucous membrane,Cecum organ mucosa,Intestinum crassum caecum mucosa,Intestinum crassum caecum mucosa of organ,Intestinum crassum caecum mucous membrane,Intestinum crassum caecum organ mucosa,Mucosa of caecum,Mucosa of cecum,Mucosa of intestinum crassum caecum,Mucosa of organ of caecum,Mucosa of organ of cecum,Mucosa of organ of intestinum crassum caecum,Mucous membrane of caecum,Mucous membrane of cecum,Mucous membrane of intestinum crassum caecum,Organ mucosa of caecum,Organ mucosa of cecum,Organ mucosa of intestinum crassum caecum,Cecum mucosa,cecum mucosa
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Response to transplant Response to transplant,response to transplant
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Alzheimer's disease(AD) patient (AD-FMT)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Apolipoprotein E (APOEe2 allele) - APOEe2-FMT
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- APOEe2 allele (APOEe2-FMT) refers to a cognitively healthy 73-year-old with the protective APOEe2 allele with genetic-related protection to AD (APOEε2 carrier), associated with no cognitive decline diagnosed, no brain amyloidosis, a high level of education, male gender.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 1
- Group 1 sample size Number of subjects in the case (exposed) group
- 1
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- arcsine square-root
- Statistical test
- MaAsLin2
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
Signature 1
Needs review
Source: Fig. 3D
Description: Differential abundance of genera between the FMT recipient mice when compared with AD-FMT
Abundance in Group 1: increased abundance in Apolipoprotein E (APOEe2 allele) - APOEe2-FMT
| NCBI | Quality Control | Links |
|---|---|---|
| Ligilactobacillus | ||
| Bilophila | ||
| Eubacterium coprostanoligenes groupEubacterium coprostanoligenes group | ||
| Parabacteroides | ||
| Prevotellaceae UCG-001Prevotellaceae UCG-001 |
Revision editor(s): KateRasheed, WikiWorks
Signature 2
Needs review
Source: Fig. 3D
Description: Differential abundance of genera between the FMT recipient mice when compared with AD-FMT
Abundance in Group 1: decreased abundance in Apolipoprotein E (APOEe2 allele) - APOEe2-FMT
Revision editor(s): KateRasheed, WikiWorks
