Personalized prediction of glycemic responses to food in women with diet-treated gestational diabetes: the role of the gut microbiota/Experiment 1

From BugSigDB


Reviewed Marked as Reviewed by Folakunmi on 2025-3-17

Curated date: 2025/03/10

Curator: Tosin

Revision editor(s): Tosin, Folakunmi

Subjects

Location of subjects
Russian Federation
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Gestational diabetes diabetes in pregnancy,GDM,gestational diabetes,gestational diabetes mellitus,maternal gestational diabetes mellitus,Gestational diabetes
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Pregnant women with lower postprandial glycemic response (PPGR) incremental area under the glycemic curve(iAUC120)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Pregnant women with higher postprandial glycemic response (PPGR) incremental area under the glycemic curve(iAUC120)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Pregnant women with higher postprandial glycemic response (PPGR) incremental area under the glycemic curve (iAUC120) (equal to or above median indices) at 120 minutes after meal.
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
2 months

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
2


Signature 1

Reviewed Marked as Reviewed by Folakunmi on 2025-3-17

Curated date: 2025/03/10

Curator: Tosin

Revision editor(s): Tosin

Source: Figure 2

Description: Results of LefSe analysis comparing relative abundance (RA) of microbial features of participants with PPGR (iAUC120) below and above median.

Abundance in Group 1: increased abundance in Pregnant women with higher postprandial glycemic response (PPGR) incremental area under the glycemic curve(iAUC120)

NCBI Quality ControlLinks
Anaerobutyricum hallii
Coprococcus comes
Corynebacteriales incertae sedis
Dorea
Fusicatenibacter
Lachnoclostridium
Lachnoclostridium edouardi
Lachnospiraceae
Lactobacillus
Marvinbryantia
Oscillospiraceae incertae sedis
Prevotella
Prevotellaceae
Roseburia
[Ruminococcus] torques
Clostridia UCG-014Clostridia UCG-014
Lachnospiraceae FCS020 groupLachnospiraceae FCS020 group
Colidextribacter

Revision editor(s): Tosin

Signature 2

Reviewed Marked as Reviewed by Folakunmi on 2025-3-17

Curated date: 2025/03/11

Curator: Tosin

Revision editor(s): Tosin

Source: Figure 2

Description: Results of LefSe analysis comparing relative abundance (RA) of microbial features of participants with PPGR (iAUC120) below and above median.

Abundance in Group 1: decreased abundance in Pregnant women with higher postprandial glycemic response (PPGR) incremental area under the glycemic curve(iAUC120)

NCBI Quality ControlLinks
Bilophila wadsworthia
Blautia
Christensenellaceae
Clostridia
Eisenbergiella tayi
Eubacterium coprostanoligenes
Muribaculaceae
Parabacteroides distasonis
Sellimonas
Oscillospiraceae UCG-002Oscillospiraceae UCG-002
Christensenellaceae R-7 groupChristensenellaceae R-7 group
Clostridia UCG-014Clostridia UCG-014
Family XIII AD3011 groupFamily XIII AD3011 group
Ruminococcus champanellensis
Lachnospiraceae UC5-1-2E3Lachnospiraceae UC5-1-2E3

Revision editor(s): Tosin