Personalized prediction of glycemic responses to food in women with diet-treated gestational diabetes: the role of the gut microbiota/Experiment 2

From BugSigDB


Reviewed Marked as Reviewed by Folakunmi on 2025-3-17

Curated date: 2025/03/11

Curator: Tosin

Revision editor(s): Tosin

Subjects

Location of subjects
Russian Federation
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Gestational diabetes diabetes in pregnancy,GDM,gestational diabetes,gestational diabetes mellitus,maternal gestational diabetes mellitus,Gestational diabetes
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Pregnant women with lower peak glycemic levels (GLUmax)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Pregnant women with higher peak glycemic levels (GLUmax)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Pregnant women with higher peak glucose levels equal to or above median
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
2 months

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
LEfSe
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No
LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
2


Signature 1

Reviewed Marked as Reviewed by Folakunmi on 2025-3-17

Curated date: 2025/03/11

Curator: Tosin

Revision editor(s): Tosin

Source: Figure 3

Description: Results of LefSe analysis comparing relative abundance (RA) of microbial features of participants with GLUmax below and above median.

Abundance in Group 1: increased abundance in Pregnant women with higher peak glycemic levels (GLUmax)

NCBI Quality ControlLinks
Eubacterium coprostanoligenes
Lachnoclostridium
Oscillospiraceae
Prevotellaceae
Clostridia UCG-014Clostridia UCG-014
Family XIII AD3011 groupFamily XIII AD3011 group
Enterococcaceae bacterium RF39

Revision editor(s): Tosin

Signature 2

Reviewed Marked as Reviewed by Folakunmi on 2025-3-17

Curated date: 2025/03/11

Curator: Tosin

Revision editor(s): Tosin

Source: Figure 3

Description: Results of LefSe analysis comparing relative abundance (RA) of microbial features of participants with GLUmax below and above median.

Abundance in Group 1: decreased abundance in Pregnant women with higher peak glycemic levels (GLUmax)

NCBI Quality ControlLinks
Butyricicoccus faecihominis
Intestinibacter bartlettii
Lachnospira eligens
Methanosphaera
Sellimonas
Family XIII AD3011 groupFamily XIII AD3011 group
Oscillospiraceae NK4A214 groupOscillospiraceae NK4A214 group
Eisenbergiella tayi

Revision editor(s): Tosin