Correlation between gut microbiota dysbiosis, metabolic syndrome and breast cancer/Experiment 2
From BugSigDB
Subjects
- Location of subjects
- Egypt
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Metabolic syndrome Cardiovascular Syndrome, Metabolic,Cardiovascular Syndromes, Metabolic,Dysmetabolic Syndrome X,Insulin Resistance Syndrome X,Metabolic Cardiovascular Syndrome,metabolic syndrome,Metabolic Syndrome X,metabolic syndrome X,Metabolic X Syndrome,Reaven Syndrome X,Syndrome X, Dysmetabolic,Syndrome X, Insulin Resistance,Syndrome X, Metabolic,Syndrome X, Reaven,Syndrome, Metabolic Cardiovascular,Syndrome, Metabolic X,X Syndrome, Metabolic,Metabolic syndrome
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- healthy controls
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- BC patients with MetS
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Female BC patients with metabolic syndrome (MetS). A confirmed case of MetS required the presence of three or more criteria: waist circumference exceeding 80 cm in females; fasting glucose levels of 100 mg/dL or higher; HDL cholesterol below 50 mg/dL in females; triglyceride levels of 150 mg/dL or higher; and blood pressure of 130/85 mmHg or higher.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 50
- Group 1 sample size Number of subjects in the case (exposed) group
- 30
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 3 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- RT-qPCR
Statistical Analysis
- Statistical test
- Kruskall-Wallis
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- Matched on Factors on which subjects have been matched on in a case-control study
- age
Signature 1
Source: Figure 3 & 4
Description: The load of Lactobacillus bacteria (Fig. 3) and Bifidobacterium bacteria (Fig. 4) in the stools of separated patients regarding metabolic syndrome and control by Kruskall–Wallis test. Bacterial group count expressed as log10 equivalent bacteria/g of feces.
Abundance in Group 1: decreased abundance in BC patients with MetS
| NCBI | Quality Control | Links |
|---|---|---|
| Lactobacillus | ||
| Bifidobacterium |
Revision editor(s): Ecsharp
