Gut microbial dysbiosis exacerbates long-term cognitive impairments by promoting intestinal dysfunction and neuroinflammation following neonatal hypoxia-ischemia/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-4-22
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Rattus norvegicus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Brain hypoxia-Ischemia Hypoxia-Ischemia, Brain,Brain hypoxia-Ischemia,brain hypoxia-Ischemia
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Sham Group
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- HI (hypoxic-ischemic) Group
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Neonatal rats that underwent hypoxia-ischema (HI) to induce brain injury
- Group 0 sample size Number of subjects in the control (unexposed) group
- 8
- Group 1 sample size Number of subjects in the case (exposed) group
- 8
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- LEfSe
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- LDA Score above Threshold for the linear discriminant analysis (LDA) score for studies using the popular LEfSe tool
- 2
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
- Chao1 Abundance-based estimator of species richness
- unchanged
- Simpson Estimator of species richness and species evenness: more weight on species evenness
- unchanged
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-4-22
Source: Figure 2I and 2J
Description: Taxonomic significant differences in gut microbiota between rats in sham group and HI (hypoxic-ischemic) group using Lefse analysis
Abundance in Group 1: increased abundance in HI (hypoxic-ischemic) Group
Revision editor(s): IsaacImitini, Tosin
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-4-22
Source: Figure 2I and 2J
Description: Taxonomic significant differences in gut microbiota between rats in sham group and HI (hypoxic-ischemic) group using LeFse analysis
Abundance in Group 1: decreased abundance in HI (hypoxic-ischemic) Group
| NCBI | Quality Control | Links |
|---|---|---|
| Akkermansiaceae | ||
| Bacteroidaceae | ||
| Enterococcaceae | ||
| Terriglobia | ||
| Verrucomicrobiales | ||
| Verrucomicrobiia | ||
| Victivallaceae | ||
| Helicobacteraceae | ||
| Caryophanaceae |
Revision editor(s): IsaacImitini, Tosin
