Gut microbial dysbiosis exacerbates long-term cognitive impairments by promoting intestinal dysfunction and neuroinflammation following neonatal hypoxia-ischemia/Experiment 5
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Rattus norvegicus
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Response to transplant Response to transplant,response to transplant
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- HI (hypoxic-ischemic) + HI (hypoxic-ischemic) FMT (fecal microbiota transplantation) group
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- HI (hypoxic-ischemic) + DEX (dexamethasone) FMT (fecal microbiota transplantation) group
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- The rats in the HI+DEX (hypoxic-ischemic + dexamethasone) group were administered (dexamethasone) DEX (ST1254, beyotime, China) orally at a dosage of 1 mg/kg daily from the 7th postnatal day to the 3rd day after HI insult.
Lab analysis
- Sequencing type
- PCR
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- T-Test
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- Matched on Factors on which subjects have been matched on in a case-control study
- age
Signature 1
Source: Figure 10C
Description: Quantification of f_Enterobacteriaceae and f_Akkermansiaceae in fecal samples between [HI (hypoxic-ischemic) + HI (hypoxic-ischemic) FMT (fecal microbiota transplantation and HI (hypoxic-ischemic) + DEX (dexamethasone) FMT (fecal microbiota transplantation) groups].
Abundance in Group 1: increased abundance in HI (hypoxic-ischemic) + DEX (dexamethasone) FMT (fecal microbiota transplantation) group
| NCBI | Quality Control | Links |
|---|---|---|
| Akkermansiaceae |
Revision editor(s): Tosin
Signature 2
Source: Figure 10B
Description: Quantification of f_Enterobacteriaceae and f_Akkermansiaceae in fecal samples between [HI (hypoxic-ischemic) + HI (hypoxic-ischemic) FMT (fecal microbiota transplantation and HI (hypoxic-ischemic) + DEX (dexamethasone) FMT (fecal microbiota transplantation) groups].
Abundance in Group 1: decreased abundance in HI (hypoxic-ischemic) + DEX (dexamethasone) FMT (fecal microbiota transplantation) group
| NCBI | Quality Control | Links |
|---|---|---|
| Enterobacteriaceae |
Revision editor(s): Tosin
