Oral microbiome diversity associates with carotid intima media thickness in middle-aged male subjects/Experiment 1

From BugSigDB


Reviewed Marked as Reviewed by Svetlana up on 2025-4-10

Curated date: 2025/04/07

Curator: Montana-D

Revision editor(s): Montana-D, KateRasheed

Subjects

Location of subjects
Finland
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Saliva Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Carotid artery intima media thickness Carotid artery intima media thickness,carotid artery intima media thickness
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Inverse association with male cIMT (carotid Intima Media Thickness)
Group 1 name Corresponds to the case (exposed) group for case-control studies
Positive association with male cIMT (carotid Intima Media Thickness)
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Subjects with Positive association with male cIMT (carotid Intima Media Thickness)

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Linear Regression
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
No
Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
blood pressure, body mass index, Confounders controlled for: "LDL (low-density lipoprotein)" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.LDL (low-density lipoprotein)


Signature 1

Reviewed Marked as Reviewed by Svetlana up on 2025-4-10

Curated date: 2025/04/07

Curator: Montana-D

Revision editor(s): Montana-D

Source: Figure 2B

Description: The association of males with low cIMT and high cIMT with statistically significant oral bacteria taxa

Abundance in Group 1: increased abundance in Positive association with male cIMT (carotid Intima Media Thickness)

NCBI Quality ControlLinks
Prevotella
Megasphaera
Veillonella

Revision editor(s): Montana-D

Signature 2

Reviewed Marked as Reviewed by Svetlana up on 2025-4-10

Curated date: 2025/04/07

Curator: Montana-D

Revision editor(s): Montana-D

Source: Figure 2B

Description: The association of males with low cIMT and high CIMT with statistically significant oral bacteria taxa.

Abundance in Group 1: decreased abundance in Positive association with male cIMT (carotid Intima Media Thickness)

NCBI Quality ControlLinks
Candidatus Absconditibacteriota
Capnocytophaga
Gemella
Fusobacterium
Neisseria
Aggregatibacter
Tannerella
Treponema
Cardiobacterium
Bacteroidales

Revision editor(s): Montana-D