Oral microbiome diversity associates with carotid intima media thickness in middle-aged male subjects/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-4-10
Subjects
- Location of subjects
- Finland
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Saliva Sailva normalis,Saliva atomaris,Saliva molecularis,Salivary gland secretion,Saliva,saliva
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Carotid artery intima media thickness Carotid artery intima media thickness,carotid artery intima media thickness
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Inverse association with male cIMT (carotid Intima Media Thickness)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Positive association with male cIMT (carotid Intima Media Thickness)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Subjects with Positive association with male cIMT (carotid Intima Media Thickness)
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- Linear Regression
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- No
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- blood pressure, body mass index, Confounders controlled for: "LDL (low-density lipoprotein)" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.LDL (low-density lipoprotein)
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-4-10
Source: Figure 2B
Description: The association of males with low cIMT and high cIMT with statistically significant oral bacteria taxa
Abundance in Group 1: increased abundance in Positive association with male cIMT (carotid Intima Media Thickness)
NCBI | Quality Control | Links |
---|---|---|
Prevotella | ||
Megasphaera | ||
Veillonella |
Revision editor(s): Montana-D
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-4-10
Source: Figure 2B
Description: The association of males with low cIMT and high CIMT with statistically significant oral bacteria taxa.
Abundance in Group 1: decreased abundance in Positive association with male cIMT (carotid Intima Media Thickness)
NCBI | Quality Control | Links |
---|---|---|
Candidatus Absconditibacteriota | ||
Capnocytophaga | ||
Gemella | ||
Fusobacterium | ||
Neisseria | ||
Aggregatibacter | ||
Tannerella | ||
Treponema | ||
Cardiobacterium | ||
Bacteroidales |
Revision editor(s): Montana-D