Fecal microbiota transplantation restores gut microbiota diversity in children with active Crohn's disease: a prospective trial/Experiment 1

From BugSigDB


Reviewed Marked as Reviewed by KateRasheed on 2025-5-12

Curated date: 2025/03/24

Curator: EniolaAde

Revision editor(s): EniolaAde, Tosin

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Crohn's disease Colitis, Granulomatous,CROHN DIS,Crohn Disease,Crohn disease,Crohn's associated gastritis,Crohn's disease,Crohn's disease of colon,Crohn's disease of large bowel,CROHNS DIS,Crohns Disease,Enteritis, Granulomatous,Enteritis, Regional,Gastritis Associated with Crohn Disease,Gastritis Associated with Crohn's Disease,granulomatous colitis,Ileitis, Regional,Ileitis, Terminal,Ileocolitis,pediatric Crohn's disease,regional enteritis,crohn disease,crohn's disease
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Healthy donors
Group 1 name Corresponds to the case (exposed) group for case-control studies
Crohn’s disease
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
Patients with Crohn's disease
Group 0 sample size Number of subjects in the control (unexposed) group
16
Group 1 sample size Number of subjects in the case (exposed) group
42

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
Spearman Correlation
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes


Signature 1

Reviewed Marked as Reviewed by KateRasheed on 2025-5-12

Curated date: 2025/03/24

Curator: EniolaAde

Revision editor(s): EniolaAde, Tosin

Source: Within-text result of "Improvement in microbial dysbiosis following oral FMT administration"

Description: Relative abundance in patients with Crohns disease vs healthy donors

Abundance in Group 1: decreased abundance in Crohn’s disease

NCBI Quality ControlLinks
Bacteroidota

Revision editor(s): EniolaAde, Tosin

Signature 2

Reviewed Marked as Reviewed by KateRasheed on 2025-5-12

Curated date: 2025/03/24

Curator: EniolaAde

Revision editor(s): EniolaAde, Tosin

Source: Within-text result of "Improvement in microbial dysbiosis following oral FMT administration"

Description: Relative abundance in patients with crohns disease and healthy donor control

Abundance in Group 1: decreased abundance in Crohn’s disease

NCBI Quality ControlLinks
Bacteroidota

Revision editor(s): EniolaAde, Tosin