Exploring the female genital tract mycobiome in young South African women using metaproteomics/Experiment 8
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-4-2
Subjects
- Location of subjects
- South Africa
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Wall of vagina Vaginal wall,Wall of vagina,wall of vagina
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Bacterial vaginosis BACT VAGINITIDES,BACT VAGINITIS,BACT VAGINOSES,BACT VAGINOSIS,Bacterial Vaginitides,Bacterial Vaginitis,Bacterial Vaginoses,bacterial vaginosis,BV,Nonspecific Vaginitis,VAGINITIDES BACT,Vaginitides, Bacterial,VAGINITIS BACT,Vaginitis, Bacterial,Vaginitis, Nonspecific,VAGINOSES BACT,Vaginoses, Bacterial,VAGINOSIS BACT,Vaginosis, Bacterial,Bacterial vaginosis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- BV- Negative (BV: Baterial Vaginosis) at Visit 1
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- BV- Positive (BV: Baterial Vaginosis) at Visit 1
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- women classified as having bacterial vaginosis (BV) based on the nugent score
- Group 0 sample size Number of subjects in the control (unexposed) group
- 47
- Group 1 sample size Number of subjects in the case (exposed) group
- 57
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 2 weeks
Lab analysis
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Mass spectrometry
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- log transformation
- Statistical test
- Linear Regression
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- vaginal pH, Confounders controlled for: "pro-inflammatory cytokines" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.pro-inflammatory cytokines
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-4-2
Source: Table S1 (supplementary file 3)
Description: Differentially abundant fungal taxa between BV-negative and BV- positive at visit 1
Abundance in Group 1: increased abundance in BV- Positive (BV: Baterial Vaginosis) at Visit 1
| NCBI | Quality Control | Links |
|---|---|---|
| Malassezia sympodialis |
Revision editor(s): Montana-D
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-4-2
Source: Table S1 (supplementary file 3)
Description: Differentially abundant fungal taxa between women with BV-negative and BV-Positive at visit 1
Abundance in Group 1: decreased abundance in BV- Positive (BV: Baterial Vaginosis) at Visit 1
Revision editor(s): Montana-D
