Gut microbiome in patients with early-stage and late-stage endometriosis/Experiment 2
From BugSigDB
Reviewed Marked as Reviewed by KateRasheed on 2025-4-29
Subjects
- Location of subjects
- China
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Endometriosis endometriosis,Endometriosis (clinical),endometriosis (disease),Endometriosis (disorder),Endometriosis (morphologic abnormality),ENDOMETRIOSIS NEC,Endometriosis NOS,Endometriosis NOS (disorder),Endometriosis of other specified sites,Endometriosis, site unspecified,Endometriosis
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Early-stage Endometriosis (Stage I-II)
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- Late-stage Endometriosis (Stage III-IV)
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Patients diagnosed with late-stage endometriosis (Stage III and Stage IV) according to the revised American Society for Reproductive Medicine (r-ASRM) classification system, confirmed by surgical and pathological examination.
- Group 0 sample size Number of subjects in the control (unexposed) group
- 39
- Group 1 sample size Number of subjects in the case (exposed) group
- 36
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 6 months
Lab analysis
- Sequencing type
- 16S
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- V3-V4
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- relative abundances
- Statistical test
- T-Test
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- unchanged
Signature 1
Reviewed Marked as Reviewed by KateRasheed on 2025-4-29
Source: Fig. 2D & Fig. S1A
Description: Differential microbes between the early- and late-stage endometriosis groups.
Abundance in Group 1: increased abundance in Late-stage Endometriosis (Stage III-IV)
Revision editor(s): Joiejoie, KateRasheed
Signature 2
Reviewed Marked as Reviewed by KateRasheed on 2025-4-29
Source: Fig. 2D & Fig. S1A
Description: Differential microbes between the early- and late-stage endometriosis groups.
Abundance in Group 1: decreased abundance in Late-stage Endometriosis (Stage III-IV)
Revision editor(s): Joiejoie, KateRasheed
