Gut microbiome in patients with early-stage and late-stage endometriosis/Experiment 8

From BugSigDB


Reviewed Marked as Reviewed by KateRasheed on 2025-4-29

Curated date: 2025/04/13

Curator: Joiejoie

Revision editor(s): Joiejoie

Subjects

Location of subjects
China
Host species Species from which microbiome was sampled. Contact us to have more species added.
Homo sapiens
Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
Dysmenorrhea Painful menstruation,Dysmenorrhea,dysmenorrhea
Group 0 name Corresponds to the control (unexposed) group for case-control studies
Early-stage-F
Group 1 name Corresponds to the case (exposed) group for case-control studies
Late-stage-F
Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
This group refers to patients without dysmenorrhea who are diagnosed with late-stage endometriosis, as examined for gut microbiota differences.
Group 0 sample size Number of subjects in the control (unexposed) group
23
Group 1 sample size Number of subjects in the case (exposed) group
19
Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
6 months

Lab analysis

Sequencing type
16S
16S variable region One or more hypervariable region(s) of the bacterial 16S gene
V3-V4
Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
Illumina

Statistical Analysis

Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
relative abundances
Statistical test
ANOVA
Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
0.05
MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
Yes


Signature 1

Reviewed Marked as Reviewed by KateRasheed on 2025-4-29

Curated date: 2025/04/15

Curator: Joiejoie

Revision editor(s): Joiejoie, KateRasheed

Source: Fig. 6D

Description: Relative abundance levels of 10 differential species consistently enriched between early-stage and late-stage groups.

Abundance in Group 1: increased abundance in Late-stage-F

NCBI Quality ControlLinks
Bombella
Commensalibacter
Snodgrassella
uncultured Hyphomicrobiales bacterium

Revision editor(s): Joiejoie, KateRasheed

Signature 2

Reviewed Marked as Reviewed by KateRasheed on 2025-4-29

Curated date: 2025/04/25

Curator: Joiejoie

Revision editor(s): Joiejoie, KateRasheed

Source: Fig. 6D

Description: Relative abundance levels of 10 differential species consistently enriched between early-stage and late-stage groups

Abundance in Group 1: decreased abundance in Late-stage-F

NCBI Quality ControlLinks
Bacteroides caecimuris
Xylanibacter ruminicola
Bacteroidales RF16 groupBacteroidales RF16 group
uncultured rumen bacterium

Revision editor(s): Joiejoie, KateRasheed