Associations of alcohol with the human gut microbiome and prospective health outcomes in the FINRISK 2002 cohort/Experiment 1
From BugSigDB
Reviewed Marked as Reviewed by Svetlana up on 2025-4-24
Subjects
- Location of subjects
- Finland
- Host species Species from which microbiome was sampled. Contact us to have more species added.
- Homo sapiens
- Body site Anatomical site where microbial samples were extracted from according to the Uber Anatomy Ontology
- Feces Cow dung,Cow pat,Droppings,Dung,Excrement,Excreta,Faeces,Fecal material,Fecal matter,Fewmet,Frass,Guano,Matières fécales@fr,Merde@fr,Ordure,Partie de la merde@fr,Piece of shit,Porción de mierda@es,Portion of dung,Portion of excrement,Portion of faeces,Portion of fecal material,Portion of fecal matter,Portion of feces,Portion of guano,Portion of scat,Portionem cacas,Scat,Spoor,Spraint,Stool,Teil der fäkalien@de,Feces,feces
- Condition The experimental condition / phenotype studied according to the Experimental Factor Ontology
- Alcohol consumption measurement Alcohol consumption measurement,alcohol consumption measurement
- Group 0 name Corresponds to the control (unexposed) group for case-control studies
- Low alcohol intake
- Group 1 name Corresponds to the case (exposed) group for case-control studies
- High alcohol intake
- Group 1 definition Diagnostic criteria applied to define the specific condition / phenotype represented in the case (exposed) group
- Individuals categorized as high-risk consumers of alcohol in Model 2
- Antibiotics exclusion Number of days without antibiotics usage (if applicable) and other antibiotics-related criteria used to exclude participants (if any)
- 6 months
Lab analysis
- Sequencing type
- WMS
- 16S variable region One or more hypervariable region(s) of the bacterial 16S gene
- Not specified
- Sequencing platform Manufacturer and experimental platform used for quantifying microbial abundance
- Illumina
Statistical Analysis
- Data transformation Data transformation applied to microbial abundance measurements prior to differential abundance testing (if any).
- centered log-ratio
- Statistical test
- Linear Regression
- Significance threshold p-value or FDR threshold used for differential abundance testing (if any)
- 0.05
- MHT correction Have statistical tests be corrected for multiple hypothesis testing (MHT)?
- Yes
- Confounders controlled for Confounding factors that have been accounted for by stratification or model adjustment
- age, body mass index, diet, sex, smoking status, Confounders controlled for: "medication use" is not in the list (abnormal glucose tolerance, acetaldehyde, acute graft vs. host disease, acute lymphoblastic leukemia, acute myeloid leukemia, adenoma, age, AIDS, alcohol consumption measurement, alcohol drinking, ...) of allowed values.medication use
Alpha Diversity
- Shannon Estimator of species richness and species evenness: more weight on species richness
- decreased
Signature 1
Reviewed Marked as Reviewed by Svetlana up on 2025-4-24
Source: Table 2, Supplementary Table 1.
Description: Differentially abundant taxa of top 10 species in model 2. For a comprehensive listing of all significant species-level results in the fully adjusted model please see Supplemental Table 1.
Abundance in Group 1: increased abundance in High alcohol intake
| NCBI | Quality Control | Links |
|---|---|---|
| Bacteroides cellulosilyticus | ||
| Tidjanibacter inops ATidjanibacter inops A | ||
| Parabacteroides B 862.066Parabacteroides B 862.066 |
Revision editor(s): Montana-D
Signature 2
Reviewed Marked as Reviewed by Svetlana up on 2025-4-24
Source: Table 2, Supplementary Table 1.
Description: Differentially abundant taxa of top 10 species in model 2.
For a comprehensive listing of all significant species-level results in the fully adjusted model please see Supplemental Table 1.
Abundance in Group 1: decreased abundance in High alcohol intake
Revision editor(s): Montana-D
