Acrorenal syndrome

Acro-renal syndrome comprises a wide spectrum of congenital malformative disorders characterized by the co-occurrence of distal limb anomalies (usually bilateral cleft feet and/or hands) and renal defects (e.g. unilateral or bilateral agenesis, ureteral hypoplasias, vesicoureteral reflux), that can be associated with a variety of extra-renal anomalies such as abdominal well defects, intestinal atresias, genital anomalies and lung malformations. Familal cases have been reported in whom an autosomal recessive inheritance was suspected.