Acute megakaryoblastic leukaemia

Acute megakaryoblastic leukemia (AMKL) is a form of acute myeloid leukemia (AML) that occurs predominantly in childhood and particularly in children with Down syndrome (DS-AMKL). Nonspecific symptoms may be irritability, weakness, and dizziness while specific symptoms include pallor, fever, mucocutaneous bleeding, hepatosplenomegaly, neurological manifestations and rarely lymphadenopathy. Acute panmyelosis with myelofibrosis may also be associated with AMKL. In contrast to DS-AMKL (around 80 % survival), non-DS-AMKL is an AML subgroup associated with poor prognosis.

Aliases

acute M7 myeloid leukemia
acute megakaryoblastic leukaemia
acute megakaryoblastic leukaemia, FAB M7
acute megakaryoblastic leukemia
acute megakaryoblastic leukemia
acute megakaryoblastic leukemia
acute megakaryoblastic leukemia (FAB type M7)
acute megakaryoblastic leukemia, FAB M7
acute megakaryocytic leukemia
acute megakaryocytic leukemias
acute myeloblastic leukemia type 7
acute myeloid leukemia M7
AMKL
AML M7
FAB M7
leukemia, megakaryocytic, malignant
megakaryocytic leukemia
megakaryocytic myelosis
thrombocytic leukaemia