Multiple system atrophy

A progressive neurodegenerative condition of the central and autonomic nervous systems characterized by atrophy of the preganglionic lateral horn neurons of the thoracic spinal cord. This disease is generally considered a clinical variant of MULTIPLE SYSTEM ATROPHY. Affected individuals present in the fifth or sixth decade with ORTHOSTASIS and bladder dysfunction; and later develop FECAL INCONTINENCE; anhidrosis; ATAXIA; IMPOTENCE; and alterations of tone suggestive of basal ganglia dysfunction. (From Adams et al., Principles of Neurology, 6th ed, p536)

Aliases

autonomic failure, Pure
hypotension, orthostatic
MSA
multiple system atrophy
Multiple system atrophy (disorder)
multisystem atrophy
orthostatic hypotension syndrome
Shy-Drager Syndrome
Shy-Drager syndrome
Shy-dragger syndrome (formerly)
Shy-McGee-Drager syndrome
susceptibility to multiple system atrophy 1